Human Papilloma Virus Infection-Changes In Cervical Epithelium and Pathogenesis |
There is excellent evidence that invasive carcinoma ofthe uterine cervix develops from abnormal cancerous surface epithelium i.e.carcinoma-in –situ. However cancer may develop from lesser degree ofhistological abnormalities or dysplasia. Etiopathogenesis of precancerous andcancerous lesions of cervix has received a great deal of attention past severaldecades. Large number of microbial agents was linked with its possibleetiology. In early days even trichomonas was once considered as causativeagents for carcinoma cervix. Later on numerous bacterial and viral agents werestudied for their causative role. In 1970s HSV-II was thought to be implicatedin abiogenesis of cancer. Further prospective studies measuring exposure topost HSV-II infection, however indicated no association for HSV-II with theprocess of cervical carcinogenesis. The most promising role of inducing cancercervix now appearing is that of HPV. It has been found in recent studies thatalmost all if not all high grades CIN lesions and invasive cancer containidentifiable HPV DNA.