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Chemical Synthesis of Dihydropyrimidine (Dhpms) Derivatives By Biginelli Reaction Using Microwave Irradiation |

Divya Verma, Sarita Parmar, Srinivasa Rao Jetti, Shubha Jain, in Journal of Advances in Science and Technology | Science & Technology


A series of spirofusedheterocycles were synthesized viacondensation of cyclic ketone, aldehyde, and urea under microwaveirradiation. The microwave assisted reaction was remarkably successful and gave𝜎 symmetric spiroheterobicyclic compounds in good yields in the presence ofDecatungstodivanadogermanic acid H6GeW10V2O40⋅ 22H2O as a catalyst under solvent-freeconditions at 800C.