An Analysis upon the Effect of the C-N+------F-C Charge Dipole Interactions within Protonated Amines: Properties of Fluorine | Original Article
Fluorine is the most chemically reactive of all the elements and combines directly (often with extreme vigor), at ordinary or elevated temperatures, with all the elements. Organo fluoro compounds and their place in pharmaceuticals and agrochemicals are introduced. The general properties of fluorine and the C-F bond are discussed. Describes the C-N+------F-C charge dipole interactions within protonated amines and explains the influence of a β fluorine on the conformation on various crystalline structures. A number of systems are synthesised which contain this charge dipole interaction. It was demonstrated that these provided a N+-C-C-F gauche torsion angle. However in the event a Grignard reaction on a fluoro cyclohexanone was found to provide an unexpected product where rearrangement followed by fluorine elimination had occurred.