The Purpose of This Research Is to Use a Bio-Nanocomposite and Microwave-Induced Diffusion Technology to Increase the Drug's Solubility and Rate of Dissolution. All Medications That Aren't Very Soluble In Water Are Chosen to Make Them More Soluble. By Transforming the Medicine into a Bionanocomposite Using the Microwave-Induced Diffusion Technique, the Solubility Is Increased. In This Study Formulation and Evaluation of Bionanocomposite Is Done By Using Mind Method. The Bionanocomposite Used Is Ketoprofen, Ibuprofen and Aceclofenac. the Solubility of Drug Is Determined By Taking the Known Excess Amount of Ketoprofen Drug into 150 Ml of Distilled Water and Kept For 24 Hrs On Magnetic Stirrer at Room Temperature. the Identification of Aceclofenac Is Done By the Ft-Ir Spectroscopy. the Wavelength Ranged from 400 to 4000 Cm−1 With a Resolution of 4 Cm−1. to Get Better Outcomes With the Modified Formulation Than We Did With the Commercially Available Formulation, The Results of This Research Suggest That Using Microwave-Generated Bnc to Increase Medication Solubility, Dissolution, and Eventually Bioavailability Might Be a Viable Option