Application
of Ozone in Heart Diseases
Madhav Mishra1*, Dr. Rajesh
Mehta2 Dr. Kanjan Upadhaya
3
1 EHS manager Teva API india Pvt. Ltd. Government Engineering College Ujjain, Chemical Engineering Department, Ujjain, MP, India
2 Medical Practitioner,
Mehta Pathology Ujjain, MP, India
3 Professor, Ujjain
Engineering College, Ujjain, MP, India
1*Madhavmishra@yahoo.co.in
2 kanjan_u@yahoo.com.in
Abstract - Rapid
changing in life style such as change in food habits, complexity in living has
resumed no. of diseases in human being. The conventional method of treating
these diseases is not effective. Hence no. of alternatives therapies comes into
existence. Ozone therapy is one such method that comes into light from last
decades. Priming result obtained has being observed with application of ozone
particularly in the treatments of wounds heart diseases cancer, HIV. An attempt
has been much in the paper to evaluate the effectiveness and feasibility of
ozone application for the curing of Heart diseases.
Key
words - Heart attack, ozone therapy, heart
failure, vessels, arteries, Cholesterol
INTRODUCTION
Ozone and oxygen
therapy is one of the most powerful and versatile therapies known today.
Research shows that action of ozone has beneficial effects on every part and
organ. Some of the effects are bacterial, fungal and viral inactivation,
circulatory enhancement, disruption of tumor metabolism, and stimulation of
oxygen metabolism.
Medical ozone is
differs from atmospheric ozone in that it is pure and concentrated this is an important
distinction because atmospheric ozone produced from UV radiation is combined
with different nitrous oxide and sulphur dioxide products and is harmful. It's
not used in medical practice.
Ozone therapy has
shown positive results in treatment of heart diseases. “Post-bypass or
angioplasty, there are chances of a re-block, it is at this point that ozone
therapy can be used to prevent a block.
Ozone therapy
involves release of singlet oxygen containing powerful antioxidant enzymes
which stimulates metabolism and the immune system. It causes red blood cells (RBCs) to release
more active oxygen at the tissue level. It relaxes blood vessel cells, opens up
small capillaries and improves circulation, killing all sorts of bacteria,
virus and fungi. It burns toxins and provides more oxygen to cells.
During First World
War (1915) ozone gas was used to purify the drinking water of major cities.
.electrically ozone is oxygen with a higher energy level. It is unstable and
high reactive. When a patient present with one of the most common forms of
Cardiovascular disease coronary heart diseases. We can think that a patient who
very likely a tissue that is hungry for oxygen and nutrients.Because the heart
is composed primarily of cardiac muscle tissue that continuously contracts and
relaxes, it must have a constant supply of oxygen and nutrients. The coronary
arteries are the network of blood vessels that carry oxygen-and nutrient-rich
blood to the cardiac muscle tissue.
Just like branches on
a tree, the coronary arteries branch into progressively smaller vessels. The
larger vessels travel along the surface of the heart; however, the smaller
branches penetrate the heart muscle. The smallest branches, called capillaries,
are so narrow that the red blood cells must travel in single file. In the
capillaries, the red blood cells provide oxygen and nutrients to the cardiac
muscle tissue and bond with carbon dioxide and other metabolic waste products,
taking them away from the heart for disposal through the lungs, kidneys and
liver.
When cholesterol plaque accumulates to the point of blocking the flow of
blood through a coronary artery, the cardiac muscle tissue fed by the coronary
artery beyond the point of the blockage is deprived of oxygen and nutrients.
This area of cardiac muscle tissue ceases to function properly. The condition when
a coronary artery becomes blocked causing damage to the cardiac muscle tissue
it serves is called a myocardial infarction or heart attack. Heart attacks occur most often as a result of
a condition called coronary artery disease (CAD). In CAD, a fatty material
called plaque (plak) builds up over many years on the inside walls of the
coronary arteries (the arteries that supply blood and oxygen to your heart).
Eventually, an area of plaque can rupture, causing a blood clot to form on the
surface of the plaque. If the clot becomes large enough, it can mostly or
completely block the flow of oxygen-rich blood to the part of the heart muscle
fed by the artery. During a heart attack, if the blockage in the coronary
artery isn’t treated quickly, the heart muscle will begin to die and be
replaced by scar tissue.
LITERATURE REVIEW
Yusuf et al., 2004: Cardiovascular diseases, comprising coronary
artery (CAD) and cerebro-vascular diseases, are currently the leading cause of
death globally, accounting for 21.9% of total deaths, and are projected to
increase to 26.3% by 2030. The factors that
coalesce to increase the risk of developing atherosclerotic CAD were
demonstrated and have subsequently been shown to be pervasive across
ethnicities and regions all over the world.
Bocci et al, 2011: Ozone administered in an appropriate dose
interval can modulate many biochemical pathways with the activation of second
messengers. The therapeutic effects of
O3 are dose-dependent. Further, obtaining an appropriate concentration of the
ozonation products is crucial to avoid toxicity.
Mustafa, 1990:
Adverse effects occur when ozonation products overwhelm the antioxidant system,
ultimately resulting in a toxic effect that leads to tissue damage. Its
mechanisms of toxicity can be summarized into the following categories.
·
Formation
of free radicals and reactive intermediates;
·
Initiation
of lipid peroxidation chain reactions
·
Oxidative
loss of functional groups and activities of biomolecules, including enzymes;
·
Alteration
of membrane permeability and functions;
·
Initiation
of secondary processes.
Re et al., 2008: O3 regulates the generation of nitric oxide
(NO), a powerful chemical mediator that can control several biological
functions, such as that of the vascular endothelium. The exposure of rat
macrophages and type II cells to O3 causes NO production by inducible NO
synthase induction.
Medical ozone therapy
(OT) is a distinct therapeutic modality which depends on the administration of
a gas mixture comprising ozone and oxygen to body fluids and cavities. The
ozone/oxygen mixture was reported to exhibit various effects on the immune
system, such as the modulation of phagocytic activity.
Bocci VA 2006 : OT
also mediated its action via oxidative products. After being administered,
ozone dissolves in biological fluids such as plasma, lymph and urine; and
immediately reacts with polyunsaturated fatty acids, antioxidants, reduced
glutathione and albumin resulting in formation of lipid peroxidation products
and H2O2. While H2O2 acts as an early and short-acting messenger, lipid
peroxidation products were distributed to the tissues via circulation and
become late and long-lasting messengers. This process stimulates the innate
immune system and helps the cell to survive when an injury occurs.
CASE STUDY
We select a patient
who have a problem relating to coronary artery diseases, we give proper orientation
There are several modalities but the most precise, where ozone and blood
antioxidants can really stoichiometrically react is ozone therapy, under the
form of a major autohemotherapy.The procedure consists in 2-3 weekly
intravenous reinfusion of 200-250 ml of the patient’s blood mixed with an equal
volume of a gas mixture composed of medical grade oxygen (~96%) and ozone
(equivalent to progressively increasing ozone doses just five minutes after
gently mixing the gas mixture with
blood). We have adopted the strategy of slowly increasing the ozone dose from
4-5 mg up to 16-20 mg (200-250 ml of blood, respectively) to gradually improve the
adaptation to the ozone stress. Thus, ozone induces a calibrated acute
oxidative stress during which a number of well defined messengers (H2O2,
4-hydroxynonenal) interact with blood and parenchymal cells and induce the up
regulation of antioxidant enzymes and HO-1. In India medical treatment is very big problem
and very expensive so ozone therapy is welcomed by such country due to inexpensive.
Recent studies to clarify the mechanism of action have shown that can be
exploited in medicine. Exposure of human blood providing exposure times and
concentrations are appropriate. Indeed unlike the respiratory system, human
blood, the components of which are in a highly dynamic state, it able to neutralize
the oxidizing power of ozone by a potent defense system. These compounds are
highly reactive and have a short half-life. Moreover, during per oxidation of
plasma lipids, there occurs formation of late effectors denominated lipid
Oxidation Products (LOPs)... ROS are also produced by the body during cell
respiration by mitochondria and during bacterial phagocytosis by leucocytes.
Most of the dose of ozone that comes into contact with blood is partly reduced
by hydrosoluble antioxidants and partly transformed into ROS and LOPS, which
are also checked by the antioxidant system of the body before they can damage
blood cells. The oxidizing action of ozone leads to the formation of hydrogen
peroxide that enters cells with various effects : in red blood cells it shifts
the hemoglobin dissociation curve to
the right and facilitates release of oxygen ; in leucocytes and endothelial
cells it favors releases of growth factors ; in all cells it stimulates long
term efficiency of antioxidant systems in adaptation to its oxidant action. We
have seen exciting result in treatment with ozone therapy. We examine result on
a 45 year old woman; we give the treatment of ozone in every 3 days. Following
result obtain The practice of autohemotherapy is some 40 years old .we observe
there is interesting change in bad cholesterol level in patient and we have
great excitement to represent this ,after ozone treatment blood PH will come to
normal level .Result before and after ozone treatment are as follows
Lipid profile |
Before ozone
therapy |
After ozone therapy |
TOTAL LIPID |
650 |
600 |
SERUM TRIGLYCERIDES |
171 |
140 |
SERUM CHOLESTEROL |
228 |
192 |
LDL CHOLESTEROL |
153.8 |
116 |
HDL CHOLESTEROL |
40 |
48 |
LDL/HDL RATIO |
3.84 |
2.41 |
There is
decrease in cholesterol but not in good cholesterol. This is very important
result because every value in normal state after ozone treatment
CONCLUSION
It can
be used as a preventative measure as we are all literally oxygen starved. It is
said that during evolution of the human body there was 38% oxygen in the
atmosphere, now there is only 17% and sometimes only 11% in polluted cities.
Hence actually a person never really gets enough oxygen to properly saturate
the healthy cells and to rid the body of toxins and we are all suffering from
hypoxia. We concluded that Ozone gives more oxygen to Red Blood Cells and
increases their glucose uptake. It makes tissue cell membranes more elastic,
pliable and healthy. It helps cells to intake nutrients efficiently and throws
out waste products quickly. It relaxes blood vessels, capillaries and increases
circulation.
The
present work in the field of Medical science and develop the ozone therapy for
treatment .of diseases. Although much remains to be done, ozone therapy is now
amenable to scientific scrutiny and attention should be concentrated on the
following points:
Ø
Accurate
dosimeter of O3 concentration
Ø
Standardization
of the procedure for O3AHT
Ø
Further
understanding of biological effects, particularly oxidative stress adaptation;
Ø
Evaluation
of any possible long-term toxicity
Ø
Evaluation
of novel approaches and rotes of O3 administration
Ø
Definition
of optimal O3 dose in different pathological conditions
Ø Randomized,
double-blind clinical studies using either O2–O3 or O2 alone versus
conventional treatment, with assessment of long-term follow up;
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