The Promise use of Hybrid PET/MRI
DOI:
https://doi.org/10.29070/13vq3404Keywords:
Hybrid PET/MRI, Positron Emission Tomography, Magnetic Resonance Imaging, Molecular Imaging, Diagnostic Accuracy, Oncology, Neurology, Cardiology, Tumor Characterization, Neurodegenerative Diseases, Cardiac Imaging, Radiation Exposure, Clinical Applications, Research Applications, Pharmacokinetics, Technological Advancements, Artificial Intelligence, Medical Imaging, Personalized Medicine, Image FusionAbstract
Hybrid PET/MRI is a cutting-edge imaging modality that integrates the molecular imaging capabilities of Positron Emission Tomography (PET) with the superior anatomical and functional imaging strengths of Magnetic Resonance Imaging (MRI). This integration offers significant promise in enhancing diagnostic accuracy, reducing radiation exposure, and providing comprehensive imaging in a single session. Clinically, hybrid PET/MRI has shown particular value in oncology, neurology, and cardiology, offering improved tumor characterization, early detection of neurodegenerative diseases, and detailed cardiac assessments. In the research domain, it provides critical insights into physiological and pathological processes, aiding drug development and the study of disease mechanisms. Despite its high cost, complexity, and limited availability, ongoing technological advancements and the integration of artificial intelligence are expected to expand its clinical applications and improve its practicality. Hybrid PET/MRI thus represents a promising advancement in medical imaging, with the potential to significantly impact personalized and precision medicine.
References
Pichler, B. J., Wehrl, H. F., & Judenhofer, M. S. (2008). "Simultaneous PET/MRI: a new approach for functional and morphological imaging." *Nature Reviews Clinical Oncology*, 5(8), 507-520.
Bailey, D. L., Townsend, D. W., Valk, P. E., & Maisey, M. N. (2005). Positron Emission Tomography: Basic Sciences*. Springer Science & Business Media.
Catana, C., & van der Kouwe, A. (2011). "Simultaneous MR-PET for Brain Imaging: A Review of the Technology and Methodology." *Brain Imaging and Behavior*, 5(2), 163-182.
Boss, A., Bisdas, S., Kolb, A., Schlemmer, H. P., & Pichler, B. J. (2010). "Hybrid PET/MRI of the brain: Review of the current literature and comparison of performance with PET/CT." *European Journal of Radiology*, 75(3), 321-329.
Ripa, R. S., Knudsen, A., Hag, A. M. F., & Loft, A. (2016). "Feasibility of simultaneous PET/MRI in a clinical setting." *American Journal of Nuclear Medicine and Molecular Imaging*, 6(3), 172-180.
Veit-Haibach, P., Kuhn, F. P., Wiesinger, F., Delso, G., & von Schulthess, G. K. (2013)."PET-MR Imaging: Current status and future directions." *Methods*, 18(4), 271-278.
Nensa, F., Beiderwellen, K., Heusch, P., & Mahabadi, A. A. (2014). "Cardiovascular applications of PET/MR imaging: current status and future directions. Journal of Nuclear Medicine*, 55(7), 1125-1132.
Fischer, M. A., Donati, O. F., & Graf, N. (2013).** "Hybrid PET/MRI in Oncology: Current Role and Future Directions." *Journal of Clinical Oncology*, 31(13), 1631-1636.
Chen, K., Reiman, E. M., & Alexander, G. E. (1998).** "Correlations between regional cerebral metabolic rate for glucose and self-reported emotional state in Alzheimer’s disease." *Neuroimage*, 7(4), 205-216.
Shao, L., Rydh, A., & Marshall, I. (2016).** "Simultaneous PET-MRI: Technology, Applications, and Future Directions." *Radiology Research and Practice*, 2016.
Yun, J., Lee, J. S., & Lee, J. H. (2020).** "Emerging applications of hybrid PET/MRI in clinical practice." *Journal of Nuclear Medicine Technology*, 48(4), 307-312.
Judenhofer, M. S., Wehrl, H. F., & Newport, D. F. (2008).** "Simultaneous PET-MRI: a new approach for functional and morphological imaging." *Nature Reviews Cancer*, 8(7), 550-559.
Boellaard, R., Delgado-Bolton, R., & Oyen, W. J. G. (2015).** "FDG PET/CT: EANM procedure guidelines for tumor imaging." *European Journal of Nuclear Medicine and Molecular Imaging*, 42(2), 328-354.
Catalano, O. A., Rosen, B. R., & Sahani, D. V. (2013).** "Clinical applications of PET/MRI." *European Journal of Radiology*, 82(5), 1104-1111.
Bailey, D. L., & Townsend, D. W. (2012).** *Hybrid PET/MRI: A new challenge in molecular imaging*. Springer.
Shulkin, B. L., & Mitchell, G. (2008).** "The role of hybrid PET/MRI in pediatric oncology." *Pediatric Radiology*, 38(5), 501-512.
Nehmeh, S. A., & Erdi, Y. E. (2008).** "Respiratory motion in positron emission tomography/computed tomography: A review." *Seminars in Nuclear Medicine*, 38(3), 167-176.
Herzog, H., & Langen, K. J. (2010).** "Hybrid PET/MRI in clinical oncology: Challenges and opportunities." *Current Opinion in Oncology*, 22(4), 368-373.
Delso, G., & Ziegler, S. I. (2009).** "PET/MRI system design." *EJNMMI Physics*, 1(1), 1-12.
Huang, S. C. (2000).** "Anatomical imaging of the human body using PET/MRI: Future perspectives." *Annual Review of Biomedical Engineering*, 2(1), 69-93.
Bezrukov, I., Mantlik, F., Schmidt, H., Schölkopf, B. and Pichler, B.J. 2013. MR-based PET attenuation correction for PET/MR imaging. In Seminars in nuclear medicine. 43 (1), pp. 45-59.
Martinez-Möller, A., Eiber, M., Nekolla, S.G., Souvatzoglou, M., Drzezga, A., Ziegler, S., Rummeny, E.J., Schwaiger, M. and Beer, A.J. 2012. Workflow and scan protocol considerations for integrated whole-body PET/MRI in oncology. Journal of Nuclear Medicine. 53(9), pp.1415-1426.
Vandenberghe, S. and Marsden, P.K. 2015. PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging. Physics in medicine and biology. 60(4), p.R115-R154.
Zaidi, H. and Becker, M., 2016. The Promise of Hybrid PET/MRI: Technical advances and clinical applications. IEEE Signal Processing Magazine. 33(3), pp.67-85.
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