Antiarthritics and Anti-Inflammatory activity of Cymbidium Species
DOI:
https://doi.org/10.29070/4qnxp337Keywords:
Cymbidium species, anti-arthritic, anti-inflammatory, phytochemicals, natural remedies, review, in vitro, in vivoAbstract
Arthritis and inflammation are prevalent health issues that significantly impact the quality of life. With the limitations and side effects associated with conventional treatments, there is a growing interest in natural remedies. Cymbidium species, a genus of orchids widely used in traditional medicine, have shown potential anti-arthritic and anti-inflammatory properties. This review aims to compile and evaluate the existing research on the therapeutic effects of Cymbidium species on arthritis and inflammation. This review aims to provide a comprehensive analysis of the anti-arthritic and anti-inflammatory activities of Cymbidium species, focusing on their phytochemical constituents, mechanisms of action, and potential as natural therapeutic agents. Cymbidium species exhibit significant anti-arthritic and anti-inflammatory activities, supported by both in vitro and in vivo studies. The bioactive compounds in these plants, particularly flavonoids and tannins, play a crucial role in their therapeutic effects. While the current findings are promising, further research, including well-designed clinical trials, is needed to confirm the efficacy and safety of Cymbidium species in human populations. This review underscores the potential of Cymbidium species as a valuable source of natural remedies for managing arthritis and inflammation, encouraging further exploration in this field.
References
Alamgeer Ambreen Malik Uttra., & Umme Habiba Hasan. (2017). Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch. BMC Complementary and Alternative Medicine, 17, 371, 1-16.
Ali, S.S., Kaosju, N., Luthra, A., Singh, A., Sharanabasava, H., Sahu, A.and Bora, U. 2020. Indian medicinal herbs as sources of antioxidants. Food Research International 41:1-15.
Chandrasekar R and Chandrasekar S. Natural herbal treatment for rheumatoid arthritis -a review. Int J Pharm Sci Res. 2017; 8(2): 368-384.
Frank-Bertoncelj M, Trenkmann M, Klein K, Karouzakis E, Rehrauer H, Bratus A, et al. Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions. Nat Commun. 2017 ; 8:14852.
Joshi R. (2023) “Chemical constituents and antibacterial property of the essential oil of the roots of Cyathocline purpurea” Journal of Ethnopharmacology 145: 621-625
Klarenbeek PL, de Hair MJ, Doorenspleet ME, van Schaik BD, Esveldt RE, van de Sande MG, Cantaert T, Gerlag DM, Baeten D, van Kampen AH, Baas F, Tak PP, de Vries N. Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease. Ann Rheum Dis. 2012; 71:1088 –1093.
Krishnamurthy A,Joshua V, Haj Hensvold A et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritisassociated autoantibody-mediated bone loss. Ann Rheum Dis. 2016; 75(4):721–729.
L.Cathrine et.al.(2021).Preliminary phytochemical analysis and anti bacteral activity of leaf extract of Vitex leucoxylon L.F, International Journal of Current Pharmaceutical Research, Vol 3, Issue 2.
Lorentzen J. (2018) “Identification of arthritogenic adjuvants of self and foreign origin” Scandinavian Journal of Immunology 49: 45-50.
Mossalem, K. L., Ghareeb, M. A., Refahy, L. A., Mohamed, A. S., Habib, M. R. (2017). Gas Chromatography-Mass Spectrometry analysis and antioxidant activity of Punica granatum L. peels and its role as Immunostimulant against Schistosoma mansoni infection in Biomphalaria alexandrina. Asian J Pharm Clin Res, 10(1), 252-258.
Newman, D.J. and Cragg, (2022). Natural products or traditional medicine as sources for invention of new drugs. Journal of Natural Product, 75:311–335
Parya Aghasafari, Uduak George and Ramana Pidaparti. “A review of inflammatory mechanism in airway diseases”. Inflamm. Res. 2019; 68: 59–74.
Paul John Peter, A. J., Yesu Raj, V. P., Prabhu Sicis, V., Joy, J., & Saravanan Sakthivel. (2012). GC-MS Analysis of bioactive components on the Leaves extract of Stylosanthes fruticosa- A potential folklore medicinal plant. Asian Journal of Plant Science and Research, 2(3), 243-253.
Pham, T. N., Nguyen, X. T., Phan, T. D., Le, T. D., Nguyen, T. B. T., Hoang, T. P. L., & Bach, L. G. (2022), Anti-arthritic activity and phytochemical composition of" Cao Khai"(Aqueous extracts of Coptosapelta flavescens Korth.). Heliyon, 8(2).
Pham, T. N., Nguyen, X. T., Phan, T. D., Le, T. D., Nguyen, T. B. T., Hoang, T. P. L., & Bach, L. G. (2022), Anti-arthritic activity and phytochemical composition of" Cao Khai"(Aqueous extracts of Coptosapelta flavescens Korth.). Heliyon, 8(2).
Roger W., Cate W. (2022) “Clinical Pharmacy and Therapeutics” 5th edition, Churchill Livingstone, Elsevier.
Rothschild B., Woods R., Rothschild C., Sebes J. (2018) “Geographic distribution of rheumatoid arthritis in ancient North America: implications for pathogenesis” Seminars in Arthritis and Rheumatism 22(3): 181-187.
Senthamil Selvan Perumal., Sanmuga Priya Ekambaram., & Dhanam, T. (2017). In vivo antiarthritic activity of the ethanol extracts of stem bark and seeds of Calophyllum inophyllum in Freund’s complete adjuvant induced arthritis, Pharmaceutical Biology, 55, 1, 1330-1336.
Sokolove J, Johnson DS, Lahey LJ, Wagner CA, Cheng D, Thiele GM, et al. Rheumatoid factor as a potentiator of anti-citrullinated protein antibodymediated inflammation in rheumatoid arthritis. Arthritis Rheumatol. 2014;66:813–821.
Tsobou Roger, et.al. (2021). Phytochemical screening and antibacterial activityof medicinal plants used to treat Typhoid feverin B amboutos division, WestCameroon. Journal of Applied Pharmaceutical Science. Vol 5(06).pp034-049.
Yadav, J. P., Singh, A. K., Grishina, M., Pathak, P., & Patel, D. K. (2022), Cucumis melo Var. agrestis Naudin as a potent antidiabetic: Investigation via experimental methods. Phytomedicine Plus, 2(4), 100340.
Zhu J, Quyyumi AA, Norman JE, et al. “Effects of total pathogen burden on coronary artery disease risk and Creactive protein levels”. Am J Cardiol. 2000; 85: 140–146.