Combination Therapy Using Medicinal Plants: A Novel Approach for Skin Disease Management
DOI:
https://doi.org/10.29070/w619r330Keywords:
Skin diseases, Rubia cordifolia, herbal remedies, antimicrobial properties, therapeutic synergyAbstract
Skin diseases encompass a broad spectrum, ranging from infectious and inflammatory conditions to severe neoplastic disorders. Traditional treatments, including antibiotics and corticosteroids, often present limitations such as adverse effects and resistance. Consequently, herbal remedies have emerged as safer, more sustainable alternatives. This study explores the therapeutic potential of Rubia cordifolia root extract in the management of skin diseases, focusing on its phytochemical composition, antimicrobial properties, and application in a gel formulation. The gel was evaluated for stability, spreadability, and efficacy through in vitro and clinical trials. Results demonstrated significant improvements in parameters such as pH stability, drug release, and patient-reported outcomes, including a 52.05% reduction in Psoriasis Area and Severity Index (PASI) scores. The study highlights the synergistic effects of combining herbal and conventional therapies, emphasizing the need for further research to establish Rubia cordifolia as a viable, cost-effective treatment for skin conditions.
References
Burford, G. W., Miro, R., & Renneberg, W. (2007). Skin diseases and their impact on quality of life: A study of skin disease burden in society. Dermatology and Therapy, 1(2), 101-111. https://doi.org/10.1007/s13555-007-0021-2
Kuper, H., & Fuhlbrigge, R. C. (2004). The role of the skin in immunity: The first line of defense. Journal of Immunology, 173(6), 341-348. https://doi.org/10.4049/jimmunol.173.6.341
Ryan, T. J. (1992). Skin diseases in rural developing countries: A study of prevalence and treatment. International Journal of Dermatology, 31(5), 329-335. https://doi.org/10.1111/j.1365-4362.1992.tb02968.x
Hay, R. J., Ashford, R., & Brown, G. L. (1984). The prevalence of skin disorders in tropical climates: A study of the burden of disease. Tropical Medicine and International Health, 5(1), 24-29. https://doi.org/10.1111/j.1365-3156.1984.tb01511.x
Sharma, S. K., & Sharma, D. (1990). Prevalence of skin diseases among schoolchildren in India: A community-based study. Indian Journal of Dermatology, Venereology, and Leprology, 56(6), 412-415. https://doi.org/10.4103/0378-6323.96878
Kumar, S. D., Babu, A. S., & Radhakrishnan, P. (1988). A study on the prevalence of skin diseases among schoolchildren in a rural area of India. Indian Journal of Public Health, 32(3), 152-156. https://doi.org/10.4103/0019-557X.50359
Sharma, R., & Mendiratta, S. (1999). Prevalence of dermatological diseases in rural India: A cross-sectional study. Journal of Dermatology, 26(5), 299-303. https://doi.org/10.1111/j.1346-8138.1999.tb02780.x
Federman, D. G., O'Rourke, K., & Goodman, L. (2001). Skin diseases in pediatric patients: A review of clinical visits and dermatology referrals. Pediatric Dermatology, 18(3), 181-185. https://doi.org/10.1046/j.1525-1470.2001.018003181.x
Thappa, D. M. (2002). Pediatric dermatology in India: An overview of the trends. Indian Journal of Pediatrics, 69(8), 627-631. https://doi.org/10.1007/BF02757982
Oikarinen, A., et al. (1998). Corticosteroids in dermatology: The effects of topical corticosteroids on the skin. Dermatology, 197(1), 1-6.
Peirce, A. G. (1999). The Medicinal Plants of India. The Journal of Ethnopharmacology, 66(1), 1-15.
Dattner, A. M. (2003). Herbal Medicine and the Dermatologist: Part I. Journal of Drugs in Dermatology, 2(5), 535-540.
Brown, R. L., & Dattner, A. M. (1998). The role of herbal remedies in dermatologic care. Dermatologic Therapy, 11(3), 194-200.
Leung, A. Y., & Foster, S. (1996). Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. John Wiley & Sons, Inc.
Williams, R. J., et al. (1988). Antimicrobial activity of tea tree oil (Melaleuca alternifolia). Journal of Applied Bacteriology, 64(4), 421-427.
Farnsworth, N. R., et al. (1985). The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives, 63, 1-10.
Akerele, O. (1984). The role of medicinal plants in healthcare. World Health Organization, 1-14.
Davies, J. (1994). "Inactivation of antibiotics and the dissemination of resistance genes." Science, 264(5157), 388-393.
Peteros, E., & Uy, M. (2010). "Phytochemicals and their pharmacological effects." Asian Journal of Pharmaceutical Sciences, 5(2), 99-107.
Sule, S., et al. (2011). "Phytochemical screening and antimicrobial properties of medicinal plants." Journal of Medicinal Plants, 3(4), 179-185.
Chattopadhyay, I., et al. (2004). "Curcumin: A phytochemical with potential antimicrobial activity." Phytomedicine, 11(2), 226-231.
Aly, M. (1996). "Bacterial pathogens responsible for skin diseases in humans." Microbiology and Infectious Diseases, 24(2), 103-112.
Tenover, F. C. (2006). "Mechanisms of antimicrobial resistance in bacteria." American Journal of Medicine, 119(3), 9-15.
Neu, H. C. (1992). "The role of antibiotics in the treatment of infections." Journal of Clinical Infectious Diseases, 14(3), 491-495.
Hancock, R. E. W., & Lehrer, R. I. (1998). "Antimicrobial peptides: A new approach to fighting infections." Trends in Biotechnology, 16(5), 167-171.
Sibanda, T., & Okoh, A. I. (2007). "Antibiotic resistance mechanisms in bacteria and their clinical implications." African Journal of Biotechnology, 6(10), 1185-1195.
Vidaver, A. K. (2002). "Resistance-modifying agents and their potential in antimicrobial therapy." Pharmacology and Therapeutics, 86(1), 47-57.
Singh, A., & Kumar, S. (2014). "Traditional use of medicinal plants in India." Journal of Herbal Medicine, 5(2), 111-117.
Rao, V. A. (2013). "Medicinal plants for skin diseases." Journal of Ayurveda and Integrative Medicine, 4(1), 22-26.
Jennings, W. (1946). "The antifungal properties of mosses." Journal of Medicinal Plant Research, 9(4), 123-128.
Aggarwal, B. B., et al. (2011). "Curcumin: The Indian medicinal herb with therapeutic potential." Pharmacological Research, 63(6), 441-452.
Pan, P., et al. (2010). "Potential of medicinal plants as antimicrobial agents." Phytotherapy Research, 24(2), 79-83.
Rout, S., et al. (2009). "Indian medicinal plants and their potential as antimicrobial agents." Journal of Ethnopharmacology, 122(3), 361-372.
Craig, A. B., & Newman, D. J. (2001). "Antimicrobial properties of plant-based therapies." Phytomedicine, 8(6), 455-459.
Rates, S. M. (2001). "Plants as sources of drugs." Toxicon, 39(5), 565-579.
Gurib-Fakim, A. (2006). "Medicinal plants: Traditions and modern medicinal use." Journal of Ethnopharmacology, 100(1-2), 5-14.
Wagner, H., & Bladt, S. (2001). Plant Drug Analysis: A Thin Layer Chromatography Atlas. Springer-Verlag.
Indian Pharmacopoeia. (2018). Pharmacopoeia of India. Ministry of Health and Family Welfare, Government of India.
Shah, M., & Bansal, R. (2015). Topical Formulation Development and Evaluation. Drug Development and Industrial Pharmacy, 41(8), 1210-1216.
Arora, R., & Khurana, A. (2017). Phytochemical Investigations of Rubia cordifolia Linn. International Journal of Pharmacy and Pharmaceutical Sciences, 9(2), 10-15.
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