A Study on Lipid Peroxidation and Coronary Artery Disease

Authors

  • Atif Shamsi Phd Student, Clinical Biochemistry, BIR Tikendrajit University, Canchipur, Imphal (Manipur)
  • Dr. Tarsem Garg Professor, BIR Tikendrajit University, Canchipur, Imphal (Manipur)

DOI:

https://doi.org/10.29070/5by99y11

Keywords:

Lipid peroxidation, coronary artery disease, oxidative stress, malondialdehyde (MDA), atherosclerosis, antioxidants, cardiovascular health

Abstract

Atherosclerosis, which causes the coronary arteries to thin or become blocked, is the main cause of coronary artery disease (CAD), which is a major cause of death and disability globally. The oxidative breakdown of lipids, a process known as lipid peroxidation, is crucial in the development of coronary artery disease (CAD). Exploring the molecular indicators of lipid peroxidation and its implications for disease development and therapy, this research analyzes the link between CAD and lipid peroxidation. The results demonstrate a robust association between the severity of CAD and higher levels of lipid peroxidation by-products, including malondialdehyde (MDA). In order to enhance clinical results, the research suggests antioxidant treatments and stresses the importance of early oxidative stress marker detection.

References

Ayala, A., Muñoz, M. F., & Argüelles, S. (2014). Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4- hydroxy-2- nonenal. Oxidative medicine and cellular longevity, 2014.

Banerjee, M., & Vats, P. (2014). Reactive metabolites and antioxidant gene polymorphisms in type 2 diabetes mellitus. Redox biology, 2, 170-177.

Bastani, A., Rajabi, S., Daliran, A., Saadat, H., & Karimi-Busheri, F. (2018). Oxidant and antioxidant status in coronary artery disease. Biomedical Reports, 9(4), 327-332.

Bhat, M. A., Mahajan, N., & Gandhi, G. (2012). Oxidative stress status in coronary artery disease patients. Int J Life Sc Bt Pharm Res, 1, 236-243.

C. E., ... & Barrett, J. C. (2005). Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?. Free Radical Biology and Medicine, 38(6), 698-710.

Davies, S. S., & Roberts II, L. J. (2011). F2-isoprostanes as an indicator and risk factor for coronary heart disease. Free Radical Biology and Medicine, 50(5), 559-566.

Dwivedi, S., Purohit, P., Misra, R., Pareek, P., Goel, A., Khattri, S., ... & Sharma, P. (2017). Diseases and molecular diagnostics: a step closer to precision medicine. Indian Journal of Clinical Biochemistry, 32(4), 374-398.

Hajar, R. (2017). Risk factors for coronary artery disease: historical perspectives. Heart views: the official journal of the Gulf Heart Association, 18(3), 109.

Kadiiska, M. B., Gladen, B. C., Baird, D. D., Germolec, D., Graham, L. B., Parker,

Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants, and functional foods: Impact on human health: Pharmacognosy Reviews, 4(8), 118.

Ninić, A., Bogavac-Stanojević, N., Sopić, M., Munjas, J., Kotur-Stevuljević, J., Miljković, M., ... & Spasojević-Kalimanovska, V. (2019). Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease. Journal of Medical Biochemistry, 38(3), 284.

Pourkeramati, A., Mehrjardi, E. Z., Tezerjani, M. D., & Seifati, S. M. (2020). Association of GSTP1, GSTT1 and GSTM1 Gene Variants with Coronary Artery Disease in Iranian Population: A Case-Control Study. International journal of general medicine, 13, 249.

Pourkeramati, A., Mehrjardi, E. Z., Tezerjani, M. D., & Seifati, S. M. (2020). Association of GSTP1, GSTT1, and GSTM1 gene variants with coronary artery disease in Iranian population: a Case-Control Study. International Journal of General Medicine, 13, 249.

Simeunovic, D., Odanovic, N., Pljesa-Ercegovac, M., Radic, T., Radovanovic, S., Coric, V., ... & Savic- Radojevic, A. (2019). Glutathione transferase P1 polymorphism might be a risk determinant in heart failure.

Torkzaban, A., Naeini, A. A., Hassanzadeh, A., & Namdari, M. (2020). A case- control study is a relationship between serum vitamin C and uric acid levels, antioxidant status, and coronary artery disease: clinical nutrition research, 9(4), 307.

Zhao, E., & Zhao, Y. (2015). Lack of association between GSTP1 Ile105Val polymorphism and coronary heart disease risk: a meta-analysis. International journal of clinical and experimental medicine, 8(10), 18488.

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Published

2022-12-01

How to Cite

[1]
“A Study on Lipid Peroxidation and Coronary Artery Disease”, JASRAE, vol. 19, no. 6, pp. 795–800, Dec. 2022, doi: 10.29070/5by99y11.

How to Cite

[1]
“A Study on Lipid Peroxidation and Coronary Artery Disease”, JASRAE, vol. 19, no. 6, pp. 795–800, Dec. 2022, doi: 10.29070/5by99y11.