Pathophysiology of Sore Throat Symptoms: A Comprehensive Review
DOI:
https://doi.org/10.29070/q934nj40Keywords:
Sore throat, pharyngitis, pathophysiology, inflammation, cytokines, neurogenic pain, Streptococcus pyogenes, viral infections, immune response, tissue damageAbstract
Sore throat, or pharyngitis, is a highly prevalent clinical symptom characterized by inflammation, pain, and irritation of the pharyngeal mucosa. It is a manifestation of various underlying conditions, most commonly viral and bacterial infections. This review delves into the pathophysiological processes underlying sore throat symptoms, including inflammatory cascades, neurogenic pain pathways, and immune-mediated tissue damage. We also explore the implications of these mechanisms for clinical practice, providing evidence-based recommendations for diagnosis and management. Specific case studies and illustrative tables are included to enhance understanding.
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References
Marom, T., et al. “Pharyngitis and sore throat: Pathophysiology and management.” Clinical Reviews (2022).
Stevens, D. L., et al. “Streptococcal pharyngitis: Clinical and pathophysiological insights.” J Infect Dis (2021).
Nakamura, K., et al. “Neurogenic inflammation in oropharyngeal pain: A review of mechanisms.” Pain Research (2019).
Moore, P. A., et al. “Pain mechanisms in sore throat: A focus on inflammatory mediators.” Pain Res Manag (2023).
Allen, T. J., et al. “Immune responses in viral and bacterial pharyngitis.” J Immunol (2020).
Kenealy, T., et al. “Sore throat management in primary care: A systematic review.” Lancet (2019).
Bisno, A. L., et al. “Acute pharyngitis: Etiology and pathophysiology.” N Engl J Med (2018).
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