F1 Female Mice Offspring Show Improved Flocculogenesis and Total Antioxidant Capacity when Treated with Hydroalcoholic Extract and Seed of Foeniculum Vulgare

Abstract

The purpose of this research was to examine Follicle formation and serum total antioxidant capacity as affected by hydroalcoholic extract from fennel seeds in prenatal and postnatal days 56 (PND 56) exposed children. There were five groups of seven pregnant NMRI mice. One group got 1000 mg/kg/day of fennel extract (FE) and 500 mg/kg/day, another group got the fifth group (CTL) took 500 and 1000 mg/kg/day in the fourth group (FS), whereas the control group got no treatment at all. Both the body and ovary weights of the treated mice increased significantly when contrasted with the CTL group. Compared to CTL children, treated offspring had a much larger corpus luteum and a greater approximate quantity of follicles in the primordial, primary, pre-antral, and pre-ovulatory stages. Both treatment groups' atretic follicle counts were not substantially lower than the CTL's. On the other hand, a more noticeable impact was seen in rats treated with 500 mg/kg FE. The CTL group's serum TAC level was much lower than that of in the FS500, FE500, and FE1000 animal groupings. The folliculogenesis of kids is improved by administering fennel seed and extract throughout pregnancy and breastfeeding. It is possible that the folliculogenesis milieu was favorably impacted by elevated concentrations of TAC in the blood of youngsters.