Recent Advances in Nanoformulation for Targeted Drug Delivery Systems
DOI:
https://doi.org/10.29070/yxrwqa98Keywords:
Nano formulation, targeted, drug, delivery, SystemsAbstract
Intravascular medication delivery allows nanoparticles to enter the circulation via blood vessels and treat intravascular illnesses by acting at precise locations inside the blood vessels. Another method of drug delivery including nanoparticles is known as extravascular drug delivery, and it involves local administration (e.g., oral, inhalation, subcutaneous injection, etc.) to target tissues. Utilising the principles of nanotechnology, nano pharmaceuticals have completely transformed the way drugs are delivered and treatment approaches in contemporary medicine. Utilising nanoparticles (NPs) and nanocarriers (NCs), these state-of-the-art formulations overcome significant drawbacks of traditional treatments by providing better targeting, increased bioavailability, and less toxicity. Their revolutionary effect on healthcare is shown by the clinical success of several nano pharmaceuticals. By decreasing the negative effects induced by systemic medications by local targeting, nonmaterial may be employed as vascular-targeted carriers for intravascular drug delivery. Intravascular inflammation changes the local environment, which may inspire new nanoparticle designs. When inflammatory stimuli are high, nanoparticles may target immune cells and the receptors on their membranes. Nanoparticle formulation of α-mangostin for cancer drug delivery system and "α-mangostin nanoparticle for cancer drug delivery system" constitute the basis of the investigation. We spoke about the possibilities and difficulties of smart systems for the targeted treatment of various vascular and non-vascular illnesses.
References
F. Bonafè et al., A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018, 68, 394–424.
Majolo, F.; de Oliveira Becker Delwing, L.K.; Marmitt, D.J.; Bustamante-Filho, I.C.; Goettert, M.I. Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery. Phytochem. Lett. 2019, 31, 196–207.
Pham, D.T.; Saelim, N.; Tiyaboonchai, W. Alpha mangostin loaded crosslinked silk fibroin-based nanoparticles for cancer chemotherapy. Colloids Surfaces B Biointerfaces 2019, 181, 705–713.
Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249.
Baskar, R.; Lee, K.A.; Yeo, R.; Yeoh, K.W. Cancer and radiation therapy: Current advances and future directions. Int. J. Med. Sci. 2012, 9, 193–199.
Tohme, S.; Simmons, R.L.; Tsung, A. Surgery for Cancer: A Trigger for Metastases. Cancer Res. 2018, 77, 1548–1552.
Swain, S.M. Chemotherapy: Updates and New Perspectives. Oncologist 2011, 16, 30–39.
Pérez-Herrero, E.; Fernández-Medarde, A. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Eur. J. Pharm. Biopharm. 2015, 93, 52–79.
Huang, C.Y.; Ju, D.T.; Chang, C.F.; Muralidhar Reddy, P.; Velmurugan, B.K. A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine 2017, 7, 12–23.
Lin, S.R.; Chang, C.H.; Hsu, C.F.; Tsai, M.J.; Cheng, H.; Leong, M.K.; Sung, P.J.; Chen, J.C.; Weng, C.F. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. Br. J. Pharmacol. 2020, 177, 1409–1423.
Nirmala, M.J.; Samundeeswari, A.; Sankar, P.D. Natural plant resources in anti-cancer therapy—A review. Res. Plant Biol. 2011, 1, 1–14.
Khan, T.; Gurav, P. PhytoNanotechnology: Enhancing delivery of plant based anti-cancer drugs. Front. Pharmacol. 2018, 8, 1002.
Subramaniam, S.; Selvaduray, K.R.; Radhakrishnan, A.K. Bioactive compounds: Natural defense against cancer? Biomolecules 2019, 9, 758.
Rejhová, A.; Opattová, A.; Cumov ˇ á, A.; Slíva, D.; Vodiˇcka, P. Natural compounds and combination therapy in colorectal cancer treatment. Eur. J. Med. Chem. 2018, 144, 582–594.
Bishayee, A.; Sethi, G. Bioactive natural products in cancer prevention and therapy: Progress and promise. Semin. Cancer Biol. 2016, 40–41, 1–3.
Davatgaran-Taghipour, Y.; Masoomzadeh, S.; Farzaei, M.H.; Bahramsoltani, R.; Karimi-Soureh, Z.; Rahimi, R.; Abdollahi, M. Polyphenol nanoformulations for cancer therapy: Experimental evidence and clinical perspective. Int. J. Nanomed. 2017, 12, 2689–2702.
Mary Lazer, L.; Sadhasivam, B.; Palaniyandi, K.; Muthuswamy, T.; Ramachandran, I.; Balakrishnan, A.; Pathak, S.; Narayan, S.; Ramalingam, S. Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin. Int. J. Biol. Macromol. 2018, 107, 1988–1998.
Cosco, D.; Mare, R.; Paolino, D.; Salvatici, M.C.; Cilurzo, F.; Fresta, M. Sclareol-loaded hyaluronan-coated PLGA nanoparticles: Physico-chemical properties and in vitro anticancer features. Int. J. Biol. Macromol. 2019, 132, 550–557.
Hamishehkar, H.; Bahadori, M.B.; Vandghanooni, S.; Eskandani, M.; Nakhlband, A.; Eskandani, M. Preparation, characterization and anti-proliferative effects of sclareol-loaded solid lipid nanoparticles on A549 human lung epithelial cancer cells. J. Drug Deliv. Sci. Technol. 2018, 45, 272–280.
Fang, R. H., Hu, C. M., Luk, B. T., Gao, W., Copp, J. A., Tai, Y., et al. (2014). Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Lett. 14 (4), 2181–2188. doi:10.1021/nl500618u
Fang, J., Islam, W., and Maeda, H. (2020). Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers. Adv. Drug Deliv. Rev. 157, 142–160. doi:10.1016/j.addr.2020.06.005
Fromen, C. A., Fish, M. B., Zimmerman, A., Adili, R., Holinstat, M., and Eniola-Adefeso, O. (2016). Evaluation of receptor-ligand mechanisms of dual-targeted particles to an inflamed endothelium. Bioeng. Transl. Med. 1 (1), 103–115. doi:10.1002/btm2.10008
Fu, J., Li, T., Yang, Y., Jiang, L., Wang, W., Fu, L., et al. (2021). Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors. Biomaterials 268, 120537. doi:10.1016/j.biomaterials.2020.120537
Gabizon, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., et al. (1994). Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54 (4), 987–992.
Galstyan, A., Markman, J. L., Shatalova, E. S., Chiechi, A., Korman, A. J., Patil, R., et al. (2019). Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy. Nat. Commun. 10 (1), 3850. doi:10.1038/s41467-019-11719-3
Galvani, S., Sanson, M., Blaho, V. A., Swendeman, S. L., Obinata, H., Conger, H., et al. (2015). HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci. Signal 8 (389), ra79. doi:10.1126/scisignal.aaa2581
Gao, J., Chu, D., and Wang, Z. (2016). Cell membrane-formed nanovesicles for disease-targeted delivery. J. Control Release 224, 208–216. doi:10.1016/j.jconrel.2016.01.024
Gao, W., Li, S., Liu, Z., Sun, Y., Cao, W., Tong, L., et al. (2017). Targeting and destroying tumor vasculature with a near-infrared laser-activated "nanobomb" for efficient tumor ablation. Biomaterials 139, 1–11. doi:10.1016/j.biomaterials.2017.05.037
Gao, X., Zhang, J., Huang, Z., Zuo, T., Lu, Q., Wu, G., et al. (2017). Reducing interstitial fluid pressure and inhibiting pulmonary metastasis of breast cancer by gelatin modified cationic lipid nanoparticles. ACS Appl. Mater Interfaces 9 (35), 29457–29468. doi:10.1021/acsami.7b05119
Gao, W., Li, X., Liu, Z., Fu, W., Sun, Y., Cao, W., et al. (2019). A redox-responsive self-assembled nanoprobe for photoacoustic inflammation imaging to assess atherosclerotic plaque vulnerability. Anal. Chem. 91 (1), 1150–1156. doi:10.1021/acs.analchem.8b04912
Gao, C., Huang, Q., Liu, C., Kwong, C. H. T., Yue, L., Wan, J. B., et al. (2020). Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nat. Commun. 11 (1), 2622. doi:10.1038/s41467-020-16439-7
Hasheminejad, N.; Khodaiyan, F.; Safari, M. Improving the antifungal activity of clove essential oil encapsulated by chitosan nanoparticules. Food Chem. 2019, 275, 113–122
Bussio, J.I.; Molina-Perea, C.; González-Aramundiz, J.V. Lower-Sized Chitosan Nanocapsules for Transcutaneous Antigen Delivery. Nanomaterials 2018, 8, 659.
Elbaz, N.M.; Owen, A.; Rannard, S.; McDonald, T.O. Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery. Int. J. Pharm. 2020, 574, 118866.
Menard, M.; Meyer, F.; Parkhomenko, K.; Leuvrey, C.; Francius, G.; Begin-Colin, S.; Mertz, D. Mesoporous silica templated-albumin nanoparticles with high doxorubicin payload for drug delivery assessed with a 3-D tumor cell model. Biochim. Biophys. Acta Gen. Subj. 2019, 1863, 332–341.
Shang, B.; Zhang, X.; Ji, R.; Wang, Y.; Hu, H.; Peng, B.; Deng, Z. Preparation of colloidal polydopamine/Au hollow spheres for enhanced ultrasound contrast imaging and photothermal therapy. Mater. Sci. Eng. C 2020, 106, 110174.
Rata, D.M.; Cadinoiu, A.N.; Atanase, L.I.; Bacaita, S.E.; Mihalache, C.; Daraba, O.M.; Gherghel, D.; Popa, M. “In vitro ” behaviour of aptamer-functionalized polymeric nanocapsules loaded with 5-fluorouracil for targeted therapy. Mater. Sci. Eng. C 2019, 103, 109828.
Jafari, S.M. (Ed.) An overview of nanoencapsulation techniques and their classification. In Nanoencapsulation Technologies for the Food and Nutraceutical Industries; Academic Press: London, UK, 2017; pp. 1–34.
Human, C.; de Beer, D.; van der Rijst, M.; Aucamp, M.; Joubert, E. Electrospraying as a suitable method for nanoencapsulation of the hydrophilic bioactive dihydrochalcone, aspalathin. Food Chem. 2019, 276, 467–474.
Habib, S.; Singh, M. Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy. Nanomaterials 2021, 11, 597.
Rodrigues, V.M.; Oliveira, W.N.; Pereira, D.T.; Alencar, É.N.; Porto, D.L.; Aragão, C.F.S.; Moreira, S.M.G.; Rocha, H.A.O.; Amaral-Machado, L.; Egito, E.S.T. Copaiba Oil-Loaded Polymeric Nanocapsules: Production and In Vitro Biosafety Evaluation on Lung Cells as a Pre-Formulation Step to Produce Phytotherapeutic Medicine. Pharmaceutics 2023, 15, 161.
Oliveira, A.C.S.; Oliveira, P.M.; Cunha-Filho, M.; Gratieri, T.; Gelfuso, G.M. Latanoprost loaded in polymeric nanocapsules for effective topical treatment of alopecia. AAPS PharmSciTech 2020, 21, 305.
Mora-Huertas, C.E.; Fessi, H.; Elaissari, A. Polymer-based drug-delivery nanocapsules. Int. J. Pharm. 2010, 385, 113–142.
Kothamasu, P.; Kanumur, H.; Ravur, N.; Maddu, C.; Parasuramrajam, R.; Thangavel, S. Nanocapsules: The weapons for novel drug delivery systems. Bioimpacts BI 2012, 2, 71–81.
Shastri, V.P. Non-degradable biocompatible polymers in medicine: Past, present and future. Curr. Pharm. Biotechnol. 2003, 4, 331–337.
Almeida, J.P.M.; Chen, A.L.; Foster, A.; Drezek, R.J.N. In vivo biodistribution of nanoparticles. Nanomedicine 2011, 6, 815–835.
Ventola, C.L. Medical Applications for 3D Printing: Current and Projected Uses. Pharm. Ther. 2014, 39, 704–711.
Goyanes, A.; Robles-Martinez, P.; Buanz, A.B.M.; Basit, A.W.; Gaisford, S. Effect of Geometry on Drug Release from 3D Printed Tablets. Int. J. Pharm. 2015, 494, 657–663.
Lim, S.H.; Kathuria, H.; Tan, J.J.Y. 3D Printing of Polymers for Biomedical Applications. Eur. Polym. J. 2020, 133, 109812.
Wang, H.; Zhou, L.; Liao, J.; Tan, W.; Liu, J.; Lin, H.; Liao, L. 3D Printing of Conductive Nanomaterials for Flexible Electronics and Energy Applications: A Review. Nanoscale 2019, 11, 19279–19304.
Zhang, B.; Li, S.; Hingorani, H.; Serjouei, A.; Larush, L.; Pawar, A.A.; Goh, W.H.; Sakhaei, A.H.; Hashimoto, M.; Kowsari, K.; et al. Highly stretchable hydrogels for UV curing based high-resolution multimaterial 3D printing. J. Mater. Chem. B. 2018, 6, 3246–3253.
Choudhury, A.; Das, S.; Bahadur, S.; Saha, S.; Roy, A. Formulation and Evaluation of 3D Printed Omeprazole Tablets. Indian J. Pharm. Sci. 2010, 72, 491–494.
Cardoso, P.H.; Araújo, E.S. An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems. Compounds 2024, 4, 71–105.
Yu, L.X. Pharmaceutical quality by design: Product and process development, understanding, and control. Pharm. Res. 2008, 25, 781–791. [Google Scholar]
Martinez-Marquez, D.; Mirnajafizadeh, A.; Carty, C.P.; Stewart, R.A. Application of quality by design for 3D printed bone prostheses and scaffolds. PLoS ONE 2018, 13, e0195291.
Dou, H.; Sun, G.; Zhang, L. CA242 as a biomarker for pancreatic cancer and other diseases. Prog. Mol. Biol. Transl. Sci. 2019, 162, 229–239.
Utkarsh, K.; Kumar, A.; Khan, A.; Nayyar, A.; Haque, S.; Iqbal, S. Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer. Genes Dis. 2022, 10, 1005–1018.
Zhao, X.; Dai, X.; Zhao, S.; Cui, X.; Gong, T.; Song, Z.; Meng, H.; Zhang, X.; Yu, B. Aptamer-based fluorescent sensors for the detection of cancer biomarkers. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2021, 247, 119038.
Li, Z.; Wang, L.; Li, Y.; Feng, Y.; Feng, W. Frontiers in carbon dots: Design, properties and applications. Mater. Chem. Front. 2019, 3, 2571–2601.
Chan, C.C.; Fan, C.W.; Kuo, Y.B.; Chen, Y.H.; Chang, P.Y.; Chen, K.T.; Hung, R.P.; Chan, E.C. Multiple serological biomarkers for colorectal cancer detection. Int. J. Cancer 2010, 126, 1683–1690
Kal-Koshvandi, A.T. Recent advances in optical biosensors for the detection of cancer biomarker α-fetoprotein (AFP). TrAC Trends Anal. Chem. 2020, 128, 115920.
Moradi, A.; Srinivasan, S.; Clements, J.; Batra, J. Beyond the biomarker role: Prostate-specific antigen (PSA) in the prostate cancer microenvironment. Cancer Metastasis Rev. 2019, 38, 333–346.
Zhang, M.; Cheng, S.; Jin, Y.; Zhao, Y.; Wang, Y. Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer. Biochim. Biophys. Acta Rev. Cancer 2021, 1875, 188503.
Chinen, A.B.; Guan, C.M.; Ferrer, J.R.; Barnaby, S.N.; Merkel, T.J.; Mirkin, C.A. Nanoparticle probes for the detection of cancer biomarkers, cells, and tissues by fluorescence. Chem. Rev. 2015, 115, 10530–10574.
Gumus, E.; Bingol, H.; Zor, E. Lateral Flow Assays for Detection of Disease Biomarkers. J. Pharm. Biomed. Anal. 2022, 225, 115206.
Hasham, K.; Ahmed, N.; Zeshan, B. Circulating microRNAs in oncogenic viral infections: Potential diagnostic biomarkers. SN Appl. Sci. 2020, 2, 442.
Treerattrakoon, K.; Roeksrungruang, P.; Dharakul, T.; Japrung, D.; Faulds, K.; Graham, D.; Bamrungsap, S. Detection of a miRNA biomarker for cancer diagnosis using SERS tags and magnetic separation. Anal. Method. 2022, 14, 1938–1945.
Tabrizi, S.; Martin-Alonso, C.; Xiong, K.; Blewett, T.; Sridhar, S.; An, Z.; Patel, S.; Rodriguez-Aponte, S.; Naranjo, C.; Shea, D. A DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies. Cancer Res. 2023, 83, 3371.
Lin, D.; Shen, L.; Luo, M.; Zhang, K.; Li, J.; Yang, Q.; Zhu, F.; Zhou, D.; Zheng, S.; Chen, Y. Circulating tumor cells: Biology and clinical significance. Signal Transduct. Target. Ther. 2021, 6, 404.
Guo, L.; Mu, Z.; Yan, B.; Wang, J.; Zhou, J.; Bai, L. A novel electrochemical biosensor for sensitive detection of non-small cell lung cancer ctDNA using NG-PEI-COFTAPB-TFPB as sensing platform and Fe-MOF for signal enhancement. Sens. Actuators B Chem. 2022, 350, 130874.
Proenca, C.A.; Baldo, T.A.; Freitas, T.A.; Materon, E.M.; Wong, A.; Duran, A.A.; Melendez, M.E.; Zambrano, G.; Faria, R.C. Novel enzyme-free immunomagnetic microfluidic device based on Co0.25Zn0.75Fe2O4 for cancer biomarker detection. Anal. Chim. Acta 2019, 1071, 59–69.
Wei, X.; Chen, K.; Guo, S.; Liu, W.; Zhao, X.-Z. Emerging microfluidic technologies for the detection of circulating tumor cells and fetal nucleated red blood cells. ACS Appl. Bio Mater. 2021, 4, 1140–1155.
Yin, B.; Qian, C.; Wang, S.; Wan, X.; Zhou, T. A microfluidic chip-based MRS immunosensor for biomarker detection via enzyme-mediated nanoparticle assembly. Front. Chem. 2021, 9, 688442.
Kulkarni, S.; Pandey, A.; Mutalik, S. Heterogeneous surface-modified nanoplatforms for the targeted therapy of haematological malignancies. Drug Discov. Today 2020, 25, 160–167.
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