The Critical Role of Pharmacist-Led Interventions in Improving Medication Adherence for Chronic Conditions: A Comprehensive Review

Authors

  • Ibrahim Saeed Ali Alshahrani Pharmacy Technician, Armed Forces Hospital Southern Region, Khamis Mushait
  • Abdulaziz Sulayman Albargan Technician Pharmacy, Armed Forces Hospital Southern Region, Khamis Mushait
  • Hassan Mohammad Alasmari Pharmacist, Armed Forces Hospital Southern Region, Khamis Mushait
  • Waleed Malmalki Technician Pharmacy, Armed Forces Hospital Southern Region, Khamis Mushait
  • Ali Saeed Alshahrani Technician Pharmacy, Armed Forces Hospital Southern Region, Khamis Mushait
  • Khaled Saeed Alshahrani Technician Pharmacy, Armed Forces Hospital Southern Region, Khamis Mushait

DOI:

https://doi.org/10.29070/2z06n929

Keywords:

Medication Adherence, Pharmacist, Intervention, Chronic Disease, Patient Education, Medication Therapy Management, Healthcare Outcomes

Abstract

Background: Medication non-adherence is a pervasive global challenge, particularly in the management of chronic diseases, leading to suboptimal health outcomes, increased morbidity and mortality, and substantial economic burden on healthcare systems. Pharmacists, as the most accessible healthcare professionals, are uniquely positioned to identify and address adherence barriers.

Objective: To comprehensively review the types, methodologies, and effectiveness of pharmacist-led interventions aimed at improving adherence to chronic medications, and to analyze the key factors contributing to their success.

Methods: A narrative review of current literature was conducted. Databases such as PubMed, Scopus, and Cochrane Library were searched for studies (randomized controlled trials, systematic reviews, meta-analyses) published between 2013 and 2023 using keywords: "pharmacist," "intervention," "medication adherence," "compliance," "chronic disease."

Results: Evidence consistently demonstrates that multifaceted pharmacist interventions significantly improve medication adherence across various chronic conditions, including hypertension, diabetes, and hyperlipidemia. Effective strategies include patient education, medication therapy management (MTM), blister packing, reminder systems, and motivational interviewing. These interventions lead to statistically significant improvements in clinical outcomes (e.g., HbA1c, BP, LDL-C control) and generate positive economic returns by reducing hospitalizations and emergency department visits.

Conclusion: Pharmacist-led interventions are a highly effective and cost-beneficial approach to tackling the problem of medication non-adherence. Integrating pharmacists as essential members of collaborative healthcare teams and compensating them for cognitive services is crucial for scaling these interventions and improving public health.

References

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Cheema, E., Sutcliffe, P., & Singer, D. R. J. (2018). The impact of interventions by pharmacists in community pharmacies on control of diseases: a systematic review. BMJ Open, 8(11), e021834.

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Mekonnen, H.S., Azmach, N.N., & Molla, F. (2023). The impact of pharmacist-led interventions on antihypertensive medication adherence in hypertensive patients: a systematic review and meta-analysis. Journal of Pharmaceutical Policy and Practice, 16(1), 45.

Pousinho, S., Morgado, M., Falcão, A., & Alves, G. (2016). Pharmacist interventions in the management of type 2 diabetes mellitus: a systematic review of randomized controlled trials. Journal of Managed Care & Specialty Pharmacy, 22(5), 493-515.

Milosavljevic, A., Aspden, T., & Harrison, J. (2018). Effectiveness of multi-compartment medication packaging adherence aids: a systematic review. International Journal of Pharmacy Practice, 26(6), 501-512.

Johnson, M. J., & Williams, M. (2015). The 5A model for pharmacist-led medication adherence intervention. Journal of the American Pharmacists Association, 55(2), e204-e215.

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Published

2025-07-01

How to Cite

[1]
“The Critical Role of Pharmacist-Led Interventions in Improving Medication Adherence for Chronic Conditions: A Comprehensive Review”, JASRAE, vol. 22, no. 4, pp. 179–183, Jul. 2025, doi: 10.29070/2z06n929.

How to Cite

[1]
“The Critical Role of Pharmacist-Led Interventions in Improving Medication Adherence for Chronic Conditions: A Comprehensive Review”, JASRAE, vol. 22, no. 4, pp. 179–183, Jul. 2025, doi: 10.29070/2z06n929.