A Review: Phytochemical and Pharmacological Investigation on Mollugo Nudicaulis Lam for Anti-Diabetic Activity
DOI:
https://doi.org/10.29070/cnefrg34Keywords:
Mollugo nudicaulis, phytochemicals, anti-diabetic activity, insulin resistance, herbal medicineAbstract
The hallmark of diabetes mellitus, a chronic metabolic disease, is persistent hyperglycemia brought on by deficiencies in either insulin action or secretion, or both. The quest for alternative therapeutic agents, such as medicinal plants with hypoglycemic potential, has become necessary due to the rising prevalence of diabetes worldwide. A lesser-known medicinal plant called Mollugo nudicaulis Lam has long been utilised for a number of therapeutic purposes, such as hepatoprotective and anti-inflammatory actions. Mollugo nudicaulis Lam's phytochemical composition, pharmacological potential, and anti-diabetic effectiveness are highlighted in this review, along with its mode of action, clinical significance, and promise for further study.
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References
1. American Diabetes Association. (2021). Standards of medical care in diabetes—2021. Diabetes Care, 44(1), S1-S232.
2. DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., & Weiss, R. (2015). Type 2 diabetes mellitus. Nature Reviews Disease Primers, 1(1), 1-22.
3. Gupta, R., Sharma, A., & Verma, S. (2020). Anti-diabetic effects of Mollugo nudicaulis extract in experimental diabetic models. Journal of Ethnopharmacology, 250, 112488.
4. Kumar, S., Mishra, A., & Pandey, A. K. (2021). Antidiabetic potential of medicinal plants. Biomedicine & Pharmacotherapy, 137, 111334.
5. Patel, D. K., Kumar, R., & Laloo, D. (2022). Herbal medicines for diabetes management. Phytomedicine, 91, 153688.
6. Powers, A. C., & D'Alessio, D. (2019). Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia. In Brunton, L., & Knollmann, B. (Eds.), Goodman & Gilman's: The Pharmacological Basis of Therapeutics (13th ed., pp. 1477-1514). McGraw Hill.
7. Rao, M. V., Anandan, S., & Chidambaram, R. (2018). Phytochemical screening of Mollugo nudicaulis. Journal of Medicinal Plants Research, 12(19), 267-273.
8. Sharma, V., Singh, R., & Gupta, P. (2019). Pharmacological evaluation of Mollugo nudicaulis for its potential anti-diabetic properties. BMC Complementary Medicine and Therapies, 19(1), 133.
9. Singh, R., Kumar, A., & Agarwal, V. (2020). A review on phytochemical and pharmacological properties of Mollugo nudicaulis. Journal of Herbal Medicine, 24, 100384.
10. World Health Organization. (2021). Global report on diabetes. WHO Press.
11. Ahmad, S., & Beg, Z. H. (2021). Phytochemicals in diabetes therapy: Mechanisms and challenges. Critical Reviews in Food Science and Nutrition, 61(15), 2487-2503.
12. Choudhury, H., Pandey, M., & Sahu, R. (2020). Role of flavonoids in diabetes treatment. Phytotherapy Research, 34(1), 472-483.
13. Das, M., & Barman, S. (2019). Antioxidant and antidiabetic potential of traditional medicinal plants. Indian Journal of Pharmacology, 51(3), 132-141.
14. Khan, M. S., & Javed, S. (2020). Natural products for diabetes treatment: Clinical evidence and mechanisms. Journal of Ethnopharmacology, 250, 112487.
15. Mishra, B. K., & Tripathi, S. (2021). Role of alkaloids in glucose metabolism regulation. Fitoterapia, 145, 104673.
16. Mohan, V., & Unnikrishnan, R. (2022). Epidemiology of diabetes in India: Current scenario and future perspectives. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 16(1), 102345.
17. Mukherjee, P. K., & Houghton, P. J. (2019). Phytochemical screening and pharmacological properties of herbal medicines. Phytomedicine, 70, 153193.
18. Pandey, S., & Tripathi, Y. B. (2020). Herbal medicines in the treatment of diabetes. Journal of Ayurveda and Integrative Medicine, 11(3), 339-347.
19. Sharma, A., & Verma, R. (2021). Mechanistic insights into the role of saponins in diabetes management. Pharmacognosy Reviews, 15(1), 21-34.
20. Srivastava, A. K., & Pandey, R. (2019). The role of tannins in glucose metabolism. Food & Function, 10(7), 3357-3372.
21. Tiwari, A. K., & Madhusudana, R. (2020). Role of traditional medicinal plants in diabetes therapy. Journal of Diabetes Research, 2020, 4653219.
22. Verma, N., & Kumar, V. (2022). Recent advancements in diabetes therapy using plant-derived compounds. Phytotherapy Research, 36(5), 2341-2360.
23. Wang, C., & Li, X. (2021). Therapeutic potential of natural antioxidants in diabetes management. Molecules, 26(6), 1832.
24. Xu, L., & Chen, W. (2020). Effects of polyphenols in diabetes therapy. Journal of Functional Foods, 67, 103847.
25. Zhao, M., & Zhang, H. (2019). Bioactive compounds from medicinal plants and their effects on diabetes. Current Pharmaceutical Design, 25(21), 2358-2371.
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