Evaluation of α-glucosidase inhibitory potential of different extracts of Cassia angustifolia extracts.

Authors

  • Chhaya Singh Research Scholar of Botany, A.P.S. University Rewa (M.P.) Author
  • Dr. I. P. Kumhar Professor of Botany, PMCOE, S.G.S. Govt. Auto. P.G. College Sidhi (M.P.) Author
  • Dr. Vivek Kumar Yadav Faculty of Biotechnology, Govt. T.R.S. College Rewa (M.P.) Author

DOI:

https://doi.org/10.29070/b8xq2287

Keywords:

Cassia angustifolia, α-Glucosidase inhibition, Methanol extract, Phytochemicals Activity, Antidiabetic activity

Abstract

This study investigated the inhibitory effect of methanol-water extract and different fractions on soil properties, herbage yield, and quality of the medicinal herb Senna. The results showed that the methanol-water extract and fractions had no significant anti-tyrosinase activity, but some fractions were active toward α-glucosidase. The hexane fraction and remaining crude extract demonstrated the highest inhibition on α-glucosidase compared to acarbose. ENC and BFM were compared with conventional farmyard manure (FYM) and chemical fertilizers (CF) in a pot experiment. Both ENC and EBC improved soil quality and fertility by increasing soil organic carbon, available nutrients, microbial biomass, and enzyme activity. ENC and BFM increased total herbage yields by 21 and 16.3% compared to FYM. The ethyl acetate fraction contained high phenolic and hydroxy anthraquinone derivatives, but no correlation was observed between the phenolic and sennoside contents of different fractions and their α-glucosidase inhibitory effect. The hexane fraction of C. angustifolia could be valuable for in vitro and in vivo antidiabetic studies and further phytochemical studies.

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References

1. Absar, N., Singh, A., Singh, A., & Singh, S. (2018). Impact of sowing and harvest times and irrigation regimes on the sennoside content of Cassia angustifolia Vahl. Industrial Crops and Products, 125, 482–490.https://doi.org/10.1016/j.indcrop.2018. 09.025

2. Bagwe, A., Bangi, S., Nete, S., Maiti, M., & Ragade, V. (2019). Evaluation of Cassia angustifolia Vahl as an immunomodulatory agent. World Journal of Pharmaceutical Sciences.

3. Bhatti, S. (2020). Phytochemical analysis and antibacterial properties of Cassia senna alata. Rawal Medical Journal, 45, 223–226.

4. Ghori, M., Wang, X., Zhang, H., Hussain, S., Qaisar, M. N., Hayat, K., Saqib, F., Zhang, X. X., Zhan, G., & Guo, Z. (2020). The genus Cassia L.: Ethnopharmacological and phytochemical overview. Phytotherapy Research, 35, 2336–2385. https://doi.org/10.1002/ptr.6954

5. Khan, S., & Verma, S. (2024). Extra-stigmatic pollen germination and pistil elongation: A novel strategy towards reproductive assurance in Dodonaea viscosa subsp. angustifolia. Australian Journal of Botany, 72. https://doi.org/10.1071/BT 22062

6. Khare, P., Kishore, K., & Sharma, D. (2017). A study on the standardization parameters of Cassia angustifolia. Asian Journal of Pharmaceutical and Clinical Research, 10, 329. https://doi.org/10.22159/ajpcr.2017.v10i7.18394

7. Kumar, D., Jain, A., & Verma, A. (2017). Phytochemical and pharmacological investigation of Cassia siamea Lamk: An insight. The Natural Products Journal, 7. https://doi.org/10.2174/2210315507666170509125800

8. Lal, R. K., Chanotiya, C. S., & Kumar, A. (2023). The prospects and potential of the horticultural and pharmacological medicinal herb senna (Cassia angustifolia Vahl.): A review. Technology in Horticulture, 3. https://doi.org/10.48130/TIH-2023-0020

9. Mahanthesh, M. C., Manjappa, A., Shinde, M., Disouza, J., & Sherikar, A. (2019). Biological activities of Cassia occidentalis Linn: A systematic review. World Journal of Pharmaceutical Research, 8, 400–417. https://doi.org/10.20959/wjpr20199-15430

10. Săvulescu, E., Georgescu, M., Popa, V., & Luchian, V. (2018). Morphological and anatomical properties of Senna alexandrina Mill. (Cassia angustifolia Vahl.). In Agriculture for Life, Life for Agriculture Conference Proceedings (Vol. 1, pp. 305–310). https://doi.org/10.2478/alife-2018-0045

11. Shah, A., Wassan, S. M., Bhatti, S., Ghanghro, A., & Ghanghro, I. H. (2020). Screening and quantitative estimation of phytochemical and biochemical components of Cassia senna (Linn.) grown at Tharparkar. International Journal of Biochemistry and Physiology, 9, 2399–2405. https://doi.org/10.31032/IJBPAS/2020/9.1.4849

12. Sivakumar, P., Karunakaran, V., Prabha, T., Chitra, M., Selvaraj, V., & Jahanmohan, K. (2024). Cassia angustifolia Vahl. https://doi.org/10.1007/978-3-031-75661-0_6

13. Vijayasekhar, V. E., Prasad, M., Joshi, D. S. D., Narendra, K., Satya, A., & Sambasiva Rao, K. R. S. (2016). Assessment of phytochemical evaluation and in-vitro antimicrobial activity of Cassia angustifolia. International Journal of Pharmaceutical Sciences, 8, 305–312.

14. Zeeshan, U., Barkat, Q., & Khalid, H. (2018). Phytochemical and antioxidant screening of Cassia angustifolia, Curcuma zedoaria, Embelia ribes, Piper nigrum, Rosa damascena, Terminalia belerica, Terminalia chebula, Zingiber officinale and their effect on stomach and liver. Matrix Science Pharma, 2, 15–20. https://doi.org/10.26480/msp.02.2018.15.20

15. Zibaee, E., Javadi, B., Sobhani, Z., Akaberi, M., Farhadi, F., Amiri, M. S., Baharara, H., Sahebkar, A., & Emami, S. A. (2023). Cassia species: A review of traditional uses, phytochemistry and pharmacology. Pharmacological Research – Modern Chinese Medicine, 9, 100325. https://doi.org/10.1016/j.prmcm.2023.100325

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Published

2026-01-01

Issue

Vol. 23 No. 1 (2026): Journal of Advances and Scholarly Researches in Allied Education (JASRAE)

Section

Articles

How to Cite

[1]
“Evaluation of α-glucosidase inhibitory potential of different extracts of Cassia angustifolia extracts”., JASRAE, vol. 23, no. 1, pp. 443–456, Jan. 2026, doi: 10.29070/b8xq2287.