Ai-Driven Predictive Tools in Hematological Disorders: A Comprehensive review of Models for Early Detection and Clinical Decision Support
DOI:
https://doi.org/10.29070/86mmzx53Keywords:
Artificial Intelligence, Hematological Disorders, Predictive Models, Early Detection, Clinical Decision SupportAbstract
There are still considerable problems to global health that are associated with haematological illnesses, such as thalassaemia, sickle cell disease, and haemophilia. This is especially true in places that have a limited diagnostic infrastructure. It is common for patients and healthcare systems to have significant problems as a result of delayed discovery and poor monitoring. These complications might include organ damage, higher mortality, and an increased financial burden. In recent years, Artificial Intelligence (AI) has emerged as a transformational tool in the field of predictive healthcare. It has opened up new pathways for early diagnosis, clinical decision support, and therapy optimisation. Identifying high-risk patients and predicting the course of disease may be accomplished through the use of AI-driven models, particularly those that are based on machine learning and deep learning techniques. These models are able to analyse complicated datasets that include imaging, laboratory biomarkers, and electronic medical records.
This paper examines the AI-based prediction tools used for haematological diseases critically, focussing on their role in early diagnosis and integration into clinical decision-making. This study synthesises data from secondary sources, including peer-reviewed research articles, clinical reports, and international health databases, to shine a light on the models' creation, architecture, and results. MRI T2* analysis for iron overload in Thalassaemia is one example of an AI application that uses imaging and has demonstrated remarkable diagnosis accuracy. In contrast, multimodal and lab-based models that rely on common biomarkers have demonstrated potential in low-resource settings for producing scalable and economical solutions.
The paper also explores the opportunities and challenges in adopting AI in urban healthcare systems, emphasizing issues such as infrastructure limitations, data fragmentation, ethical concerns, and the absence of comprehensive regulatory frameworks. In order to help healthcare practitioners, lawmakers, and academics understand how AI might improve predictive healthcare and lessen the burden of disease, this paper uses secondary data to offer evidence-based ideas. To completely incorporate AI into haematology and develop sustainable, patient-centered healthcare models, the results highlight the need of focused investments, ethical standards, and ongoing innovation.
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References
1. Abdalla, H. B., Ahmed, A., Li, G., Mustafa, N., & Sangi, A. R. (2023). Transfer learning with deep maxout networks for thalassemia detection. arXiv preprint.
2. Adeyemi, T., & Singh, P. (2023). Hospitalization and disease burden in sickle cell disease: a review. Journal of Global Hematology, 8(1), 56–68.
3. Ahmed, A., Nagy, A., Kamal, A., & Farghl, D. (2022). Leukemia detection using CNN-based blood smear classification. arXiv preprint.
4. Alhejaily, A. M. G., & colleagues. (2024). Artificial intelligence in healthcare: Innovations, applications, and challenges. BMC Medical Education, 24(1), 145–162.
5. Ameen, S., Balachandran, R., & Theodoridis, T. (2024). Deriving hematological disease classes using fuzzy logic and expert knowledge: A machine learning approach using CBC parameters. Journal of Clinical Medical Informatics, 22(1), 45–59.
6. Avanzo, M., & colleagues. (2024). The evolution of artificial intelligence in medical imaging. Scientific Reports, 14, 30116.
7. Chakraborty, A., & Sharma, Y. (2024). Economic challenges of Thalassemia management in India. Public Health Economics Review, 5(2), 133–146.
8. Choi, A., Lee, K., Hyun, H., Kim, K., Ahn, B., Hahn, S., & Kim, J. H. (2024). A novel deep learning algorithm for real time prediction of clinical deterioration in the emergency department. Scientific Reports, 14, 30116.
9. Eguia, H., & colleagues. (2024). Clinical decision support and natural language processing: systematic review and future directions. Journal of Medical Internet Research, e55315.
10. El Alaoui, Y., & colleagues. (2022). A review of artificial intelligence applications in hematology. Journal of Medical Internet Research, 24(7), e36490.
11. Evans, M., & Park, S. (2025). Early risk-prediction in hematology using AI algorithms. Computational Medicine Journal, 12(1), 78–89.
12. Fernandes, R., & Das, S. (2024). Population screening and prevention strategies for hemoglobin disorders. Community Genetics Journal, 9(2), 44–57.
13. Goswami, N. G., Sampathila, N., Bairy, G. M., Goswami, A., & Siddarama, D. D. (2024). Explainable deep learning for sickle cell detection in blood smears using XAI. Information, 15(7), 403.
14. Huang, L., & Diaz, E. (2023). Global burden of Thalassemia: incidence and regional disparities. International Journal of Genetic Disorders, 6(3), 170–185.
15. Imaging Informatics overview. (2025). Advancements in AI and deep learning: impact on radiomics and diagnostic systems. Imaging Informatics Annual Review, 8(1), 45–59.
16. Khalil, A., & Alghamdi, R. (2024). AI-supported risk assessment for iron overload in Thalassemia patients. International Journal of Hematological Informatics, 5(2), 112–121.
17. Khosravi, M., & colleagues. (2024). Artificial Intelligence and Decision Making in Healthcare: Clinical implications and adoption. PLOS ONE, e10916499.
18. Lee, K. H., & colleagues. (2024). Machine learning based clinical decision support system for treatment recommendation and overall survival prediction of hepatocellular carcinoma: a multi center study. npj Digital Medicine, 7(1), 1–11.
19. Liao, H. (2025). Application of artificial intelligence in laboratory hematology. Clinical Hematopathology Bulletin, 7(1), 88–100.
20. Long, Y. (2024). Predictive machine learning model for thalassemia detection in pregnancy: large scale blood routine screening. Frontiers in Hematology, 7, 134122.
21. López, F., & Barfield, S. (2023). Hemophilia treatment access and global inequalities. Bleeding Disorders Research, 11(1), 45–58.
22. Mahmood, F., & Zubair, H. (2024). Predictive analytics for hematology clinical decision support. Journal of Laboratory Medicine, 19(1), 67–78.
23. Mehta, R., & Aggarwal, S. (2025). Clinical complications in transfusion dependent Thalassemia: current perspectives. Hematology Today, 15(2), 75–90.
24. Mehta, R., & Aggarwal, S. (2025). Systemic complications of iron overload in Thalassemia patients. International Journal of Hemoglobin Disorders, 14(1), 60–74.
25. Morgan, C., & Patel, J. (2025). Dashboard-based predictive tools in hematology clinics. Clinical Decision Support Quarterly, 3(1), 34–46.
26. Morris, C., & Tanaka, A. (2024). Newborn screening for Thalassemia: outcomes and global impact. Journal of Preventive Hematology, 14(1), 21–34.
27. Musallam, K. M., & colleagues. (2023). Global map of Thalassemia prevalence and evidence gaps. American Journal of Hematology, 98(6), 102–110.
28. Narayanan, V., Kumar, S., & Rao, P. (2023). AI-assisted carrier screening in Indian tertiary hospitals. Journal of Genetic Screening, 8(3), 88–95.
29. Nasir, M. U., & colleagues. (2025). Multiclass classification of Thalassemia types using AI-based imaging. Scientific Reports, 15(45), 345–356.
30. Obeagu, E. I. (2025). Revolutionizing hematological disorder diagnosis. Annals of Medicine and Surgery, 20(4), 110–124.
31. Okafor, E., & Behnam, S. (2024). Mortality trends in sickle cell disease in sub Saharan Africa. African Medical Review, 7(3), 109–122.
32. Patel, R., & Kapoor, H. (2024). Error reduction and decision-making improvement with AI in hematology. Healthcare AI Fundamentals, 2(2), 99–107.
33. Patel, R., & Srinivasan, K. (2025). Long-term cost of Thalassemia in South Asian economies. Journal of Healthcare Economics, 10(1), 110–123.
34. Pérez, R., & Lim, T. (2023). AI-based imaging models for early detection of iron overload in Thalassemia. Journal of Radiological Informatics, 9(2), 145–156.
35. Prentzas, N., Kakas, A., & Pattichis, C. S. (2023). Explainable AI applications in the medical domain: systematic review. arXiv (preprint).
36. Preti, L. M., & colleagues. (2024). Implementation of machine learning applications in health care: barriers and enablers. Journal of Medical Internet Research, e55897.
37. Qasem, S. N., & Mosavi, A. (2020). Meta heuristic dynamic harmony search for differentiating IDA and β thalassemia trait using CBC indices. arXiv preprint.
38. Rao, E., & Kapoor, H. (2023). Epidemiology and burden of Sickle Cell Disease. Journal of Hemoglobin Disorders, 9(2), 98–112.
39. Roy, S., & Mehta, P. (2023). AI integration into urban hospital workflows for Thalassemia management. Urban Healthcare Innovations, 4(1), 45–57.
40. Roy, S., & Mehta, P. (2023). Predictive analytics in chronic hematological disease management. AI in Chronic Care, 6(1), 33–45.
41. Saputra, D. C. E., Ibrahim, M., Abbas, S., Fatima, A., & Elmitwally, N. (2023). Anemia classification based on hybrid ELM and clinical pathology data. PMCID preprint
42. Schouten, D., Nicoletti, G., Dille, B., Chia, C., Vendittelli, P., Schuurmans, M., & Khalili, N. (2024). Navigating the landscape of multimodal AI in medicine: a scoping review on technical challenges and clinical applications. arXiv (preprint).
43. Singh, N., & Tan, H. (2025). Machine learning in sickle cell disease prognosis: new tools and outcomes. Blood Disorders Analytics, 6(1), 50–62.
44. Smith, J., & Patel, H. (2024). Global epidemiology of Thalassemia and carrier prevalence. International Journal of Genetic Disorders, 5(1), 30–42.
45. Subramanian, B., & colleagues. (2025). Autonomous AI for multi-pathology detection in Indian healthcare. arXiv preprint.
46. Tan, Y., & Lim, T. (2025). Deployment of scalable CBC-based AI tools in developing country clinics. Journal of Medical Artificial Intelligence, 6(2), 121–130
47. The Washington Post. (2025, April 5). AI hasn’t killed radiology, but it is changing it. The Washington Post. Retrieved from https://www.washingtonpost.com
48. Verywell Health. (2023, November 18). From EKGs to X ray analysis, here’s how your doctor is actually using AI. Verywell Health. Retrieved from https://www.verywellhealth.com






