Fungicidal Activity of Novel Synthesized 2-(N-Aryloxy Acetyl)-5-(2'-Hydroxy Phenyl)-1, 3, 4-Oxadiazole

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Published: Sep 2, 2024
DOI: https://doi.org/10.29070/hm0s4h11
Keywords:
Fungicidal Activity , Novel Synthesized, 2-(N-Aryloxy Acetyl)-5-(2'-Hydroxy Phenyl)-1, 3, 4-Oxadiazole

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Authors

Ashwini Kumar

Research Scholar, P.G. Dept. of Chemistry, Magadh University, Bodh Gaya, Bihar

Abstract

After a novel set of 2-(N-aryloxy acetyl)-5-(2'-hydroxy phenyl)-1,3,4-oxadiazole derivatives were created, their fungicidal ability was evaluated.   A mild condensation reaction of salicylic acid hydrazide with various aryloxyacetic acid chlorides produced the necessary heterocyclic molecules.   The compounds' in vitro antifungal efficacy against a panel of phytopathogenic fungi, including Aspergillus niger, Rhizoctonia solani, and Fusarium oxysporum, was evaluated using the poisoned food technique.   Numerous substances had significant inhibitory effects, with certain modifications enhancing the fungicidal efficacy.   The results indicate that the 1,3,4-oxadiazole scaffold including hydroxyaryl and N-aryloxyacetyl groups has the potential to be used to make powerful agrochemical fungicides.

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Issue

Vol. 21 No. 2 (2024): Journal of Advances in Science and Technology (JAST)

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