Article Details

A Study on the Biological Evaluation of Dihydropyridines | Original Article

Surabhi Singh*, in Journal of Advances and Scholarly Researches in Allied Education | Multidisciplinary Academic Research


By substituting 1-(4-Nitrobenzyl)-5-imidazolyl or 2-methylthio-1-(4-Nitrobenzyl)-5-imidazolyl for the orthonitrophenyl group on location 4, new analogues of nifedipine, an established calcium channel blocker, were synthesised. In male rats, the effects of the newly synthesised compounds on blood pressure were analysed using an indirect tail-cuff procedure at 15, 30, and 60 minutes after administration and compared to nifedipine.