A Study on Cyanopyridones Synthesis and Biological Evaluation

Synthesis, Activity, and Screening of Cyanopyridone Derivatives

Abstract

Cyanopyridone derivatives are generated by both microwave assisted and conventional methods. The condensation of chalcones with ethylcyanoacetate in the presence of ammonium acetate in ethanol leads to cyanopyridones. In microwave synthesis, the reactions are considerably faster and the yields are significantly higher. The rapid assembly of molecular diversity is an important goal of synthetic organic chemistry and is one of the key paradigms of modern drug discovery. On the other hand, cyanopyridone and cyanopyridine derivatives have shown to posses promising antimicrobial and anticancer activities. we have designed and synthesized a series of 4,6-disubstituted-3- cyano-2-pyridone derivatives (4a-o) via one-pot multicomponent reaction using 3-substituted- 1H-pyrazole-4-carbaldehydes (1a-e), various acetyl compounds (2a-c), ethyl cyanoacetate (3) and ammonium acetate. All the target molecules were screened for their antimicrobial activity against various microorganisms.