Phytochemical Screening and Hypoglycemic Activity of Aqueous, Ethanolic and Methanolic Extracts of Syzygium Cumini and Phyllanthus Amarus in Streptozotocin Induced Diabetic Rats

Evaluation of the anti-diabetic potential of Syzygium cumini and Phyllanthus amarus extracts

Abstract

Type II diabetes has become an epidemic in the 21st century where India leads the world with largest number of diabetic subjects. Traditional medicines are obtained from medicinal plants and are used by about 40-60 of the world’s population. Though there are many approaches to control diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. Syzygium cumini and Phyllanthus amarus are medicinal plants used for the potential management of diabetes mellitus. The leaves are used in herbal medicinal preparation. The concerned study reveals the anti-diabetic potential of Syzygium cumini seeds and Phyllanthus amarus leaves in controlling blood glucose level in Streptozotocin induced Diabetic rats. Bioactive compounds like Mycaminose in Syzygium cumini seeds and bioactive compounds like lighans, and galloatnoids, may be responsible for the significant stimulation of β-cells of pancreas in the production of Insulin. In the current work we have studied the anti-diabetic effect of the aqueous, ethanolic and methanolic extracts of Syzygium cumini and Phyllanthus amarus on streptozotocin induced diabetic rats. The ethanolic and methanolic extracts of Syzygium cumini had significantly reduced the blood glucose levels than the aqueous extracts. Similarly the methanolic and aqueous extracts of Phyllanthus amarus, has significantly reduced the blood glucose levels than the ethanolic extract