An Investigation into the Biological Effects of Dihydropyrimidines

Exploring the Biginelli reaction and diverse biological properties of dihydropyrimidones

Abstract

A class of heterocyclic compounds known as dihydropyrimidonesthiones was initially discovered in 1893 by P. Biginelli. It has a wide range of biological actions, including anti tubercular, anti-malarial, anticancer, anti-HIV activity, analgesic, antiepileptic, cns activity, anti-inflammatory, and antitumor activity. According to this review, dihydropyrimidones' biginelli reaction and biological properties are briefly discussed.