A Review Study on Reverse Phase HPLC & UV-Visible Methods for Active Pharmaceutical Ingredients [API] in Pure and Their Formulations Metformin-Canagliflozin

Development and validation of a simple UV spectrophotometric method for determining Canagliflozin in bulk and pharmaceutical formulations

Authors

  • Chahar Devendra Singh Author
  • Dr. U. S. Sharma Author

Keywords:

reverse phase HPLC, UV-Visible methods, active pharmaceutical ingredients, API, Metformin-Canagliflozin, bulk, pharmaceutical formulations, ICH Guidelines, double beam UV Spectrophotometric method, linearity, precision, repeatability, accuracy, robustness, ruggedness, phosphate buffer, absorbance, Beer's law, concentration range

Abstract

To develop and validate simple, sensitive, precise, rapid and cost effective method for determination of Canagliflozin in bulk and pharmaceutical formulations as per ICH Guidelines. A simple double beam UV Spectrophotometric method has been developed and validated with different parameters such as Linearity, Precision, Repeatability, Accuracy, Robustness and Ruggedness. Canagliflozin in phosphate buffer shows maximum absorbance at 240 nm. Beer’s law was obeyed in the concentration range of 10-50 mcg ml-1.

Downloads

Download data is not yet available.

Downloads

Published

2019-05-01

Issue

Vol. 16 No. 6 (2019): Journal of Advances and Scholarly Researches in Allied Education (JASRAE)

Section

Articles

How to Cite

[1]
“A Review Study on Reverse Phase HPLC & UV-Visible Methods for Active Pharmaceutical Ingredients [API] in Pure and Their Formulations Metformin-Canagliflozin: Development and validation of a simple UV spectrophotometric method for determining Canagliflozin in bulk and pharmaceutical formulations”, JASRAE, vol. 16, no. 6, pp. 1520–1525, May 2019, Accessed: Apr. 04, 2026. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/11588