Factors Affecting Immune Response System

Understanding the Impact of Genetic Variations on Immune Response

Abstract

Dysregulated serum proteins (cytokines) profiles relate to several immune mediated disorders. Strong correlation exists between cytokine genes and immune mediated diseases, i.e., SLE are dominated by interferon-inducible gene within the blood however, the pathological influence of such genetic associations is already difficult to understand.Recent inter-individual variations studies on APC and T-cells results estimated about 22 variation as genetically heritable factors and suggest its moderate contribution to affect blood transcriptomes. All these information gave us an estimation of variations among the individuals within a population.