Synthesis, Characterisation and Pharmacological Studies of Some New Indole Clubbed Chalcones and Its Derivatives Pyrazoline and Pyrimidine as Antiinfective Agents
Design, Synthesis, and Proficiency Screening of Indole Clubbed Chalcones and Their Pyrazoline and Pyrimidine Derivatives as Antiinfective Agents
Keywords:
Synthesis, Characterisation, Pharmacological Studies, Indole Clubbed Chalcones, Derivatives Pyrazoline, Derivatives Pyrimidine, Antiinfective Agents, Multidrug Resistant Bacteria, Combinatorial Library, Heterocyclic Derivatives, FTIR, 1H NMR, 13C NMR, Elemental Analysis, In vitro antimicrobial, Antitubercular Proficiency, Selected PathogensAbstract
With the aim to discover new innovative antiinfective agents or to control multidrug resistant bacteria, a combinatorial library of some new heterocyclic derivatives pyrazoline (6a-e) and pyrimidine (7a-e) ring systems incorporate indole nucleous were designed and synthesised from chalcones. Chalcones (5a-e) react with hydrazine hydrate and guanidine hydrochloride gives 1-acetyl pyrazoline (6a-e) and 2-amino pyrimidine (7a-e) derivatives respectively. Confirmation of structures was assigned on the basis of FTIR, 1H NMR, 13C NMR spectral data as well as elemental analysis. In vitro antimicrobial as well as antitubercular proficiency of the title compounds were screened against selected pathogens. Compounds 5b, 5c, 5e, 6c, 7b and 7c exhibited excellent antimicrobial activity and said to be the most proficient members of the series.Published
2019-06-01
How to Cite
[1]
“Synthesis, Characterisation and Pharmacological Studies of Some New Indole Clubbed Chalcones and Its Derivatives Pyrazoline and Pyrimidine as Antiinfective Agents: Design, Synthesis, and Proficiency Screening of Indole Clubbed Chalcones and Their Pyrazoline and Pyrimidine Derivatives as Antiinfective Agents”, JASRAE, vol. 16, no. 9, pp. 442–450, Jun. 2019, Accessed: Sep. 20, 2024. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/12236
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How to Cite
[1]
“Synthesis, Characterisation and Pharmacological Studies of Some New Indole Clubbed Chalcones and Its Derivatives Pyrazoline and Pyrimidine as Antiinfective Agents: Design, Synthesis, and Proficiency Screening of Indole Clubbed Chalcones and Their Pyrazoline and Pyrimidine Derivatives as Antiinfective Agents”, JASRAE, vol. 16, no. 9, pp. 442–450, Jun. 2019, Accessed: Sep. 20, 2024. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/12236