Bark as Medicine: A Systematic Review of Pharmacological Properties and Therapeutic Benefits of Medicinal Plant Barks

Authors

  • Priyanka Solanki Research Scholar, Department of Botany Madhyanchal Professional University, Ratibad, Bhopal, Madhya Pradesh
  • Dr. Satish Mohabe Associate Professor, Department of Botany Madhyanchal Professional University, Ratibad, Bhopal, Madhya Pradesh

Keywords:

bark, pharmacological properties, therapeutic benefits, medicinal plant barks, structure, chemical composition, phytochemicals, anti-inflammatory, antimicrobial, antioxidant, antidiabetic, antitumor, traditional remedies, contemporary scientific understanding, medicinal plant barks diversity, therapeutic applications, modern medicine

Abstract

Plant bark, a multifaceted structure integral to the survival and function of woody plants, haslong been recognized for its diverse pharmacological properties. This systematic reviewcomprehensively explores the pharmacological effects and therapeutic potential of medicinal plantbarks. The structure and chemical composition of plant bark are elucidated, shedding light on theintricate layers and tissues that contribute to its protective functions, nutrient transport, andenvironmental interactions. The pharmacological exploration encompasses a myriad of bioactivecompounds found in plant barks, including alkaloids, phenols, tannins, flavonoids, terpenoids, andglycosides. The review synthesizes current knowledge on the major pharmacological activitiesassociated with plant barks, emphasizing their anti-inflammatory, antimicrobial, antioxidant, antidiabetic,and antitumor properties. The anti-inflammatory potential of certain plant barks, exemplified by WhiteWillow's salicin content, reveals promising avenues for addressing inflammatory conditions.Additionally, the antimicrobial efficacy of bark compounds, such as quinine from Cinchona trees andcinnamaldehyde from Cinnamon trees, positions them as valuable agents in combating infectiousdiseases. The antioxidant activity of phenolic-rich barks emerges as a crucial factor in mitigatingoxidative stress-related disorders, while select barks show antidiabetic effects, offering potentialinterventions for diabetes management. Furthermore, the review explores the burgeoning field ofresearch on plant barks with antitumor activity, presenting a promising frontier in the quest for novelanticancer agents.Throughout history, diverse cultures have harnessed the medicinal benefits of plant barks, and thisreview bridges traditional remedies with contemporary scientific understanding. The collective findingsunderscore the rich pharmacological diversity housed within medicinal plant barks, inviting furtherresearch and exploration of their therapeutic applications in modern medicine.

References

Shrestha PM, Dhillion SS. Medicinal plant diversity and use in the highlands of Dolakha district, Nepal. Journal of Ethnopharmacology. 2003;86(1):81-96

Asase A, Kokubun T, Grayer RJ, Kite G, Simmonds MSJ, Oteng-Yeboah AA, et al. Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia sieberiana, Haematostaphisbarteri, Mitragynainermis and Pseudocedrelakotschyi. Phytotherapy Research. 2008;22(8):1013-1016

Sarkar S, Zaidi S, Chaturvedi AK, Srivastava R, Dwivedi PK, Shukla R. Search for a herbal medicine: Antiasthmatic activity of methanolic extract of Curcuma longa. Journal of Pharmacognosy and Phytochemistry. 2015;3:59-72

Fischer PR, Bialek R. Prevention of malaria in children. Clinical Infectious Diseases. 2002;34(4):493-498

WHO. World Malaria Report 2014. Washington, DC: World Health Organization; 2015

Tabuti JRS. Herbal medicines used in the treatment of malaria in Budiopecounty, Uganda. Journal of Ethnopharmacology. 2008;116(1):33-42

Zirihi GN, Mambu L, GuédéGuina F, Bodo B, Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology. 2005;98(3):281-285

Basco LK, Mitaku S, Skaltsounis A-L, Ravelomanantsoa N, Tillequin F, Koch M, et al. In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 1994;38(5):1169-1171

Chiyaka C, Garira W, Dube S. Effects of treatment and drug resistance on the transmission dynamics of malaria in endemic areas. Theoretical Population Biology. 2009;75(1):14-29

Ameyaw Y. Morpho-histological characters for the identification of Cryptolepissanguinolenta (Lindl.) Schtr. International Journal ofScience and Nature. 2012;3(2):331-339

Irvine FR. Woody plants of Ghana. In: Woody Plants of Ghana. England, UK: Oxford University Press; 1961

Boye GL, Ampofo O. Proceedings of the First International Symposium on Cryptolepine. Kumasi, Ghana: University of Science and Technology; 1983

Wright CW, Phillipson JD, Awe SO, Kirby GC, Warhurst DC, QuetinLeclercq J, et al. Antimalarial activity of cryptolepine and some other anhydronium bases. Phytotherapy Research. 1996;10(4):361-363

Paulo A, Gomes ET, Steele J, Warhurst DC, Houghton PJ. Antiplasmodial activity of Cryptolepissanguinolenta alkaloids from leaves and roots. Planta Medica. 2000;66(01):30-34

Bugyei KA, Boye GL, Addy ME. Clinical efficacy of a tea-bag formulation of Cryptolepissanguinolenta root in the treatment of acute uncomplicated falciparum malaria. Ghana Medical Journal. 2010;44(1):3-9

Burkill HM. The Useful Plants of West Tropical Africa. 2nd ed. Vol. 1. Kew: Royal Botanic Gardens; 1985

Oliver-Bever BEP. Medicinal Plants in Tropical West Africa. England: Cambridge University Press; 1986

Agyare C, Asase A, Lechtenberg M, Niehues M, Deters A, Hensel A. An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana. Journal of Ethnopharmacology. 2009;125(3):393-403

Komlaga G, Cojean S, Dickson RA, Beniddir MA, Suyyagh-Albouz S, Mensah MLK, et al. Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana. Parasitology Research. 2016;115(8):3185-3195

Annan K, Sarpong K, Asare C, Dickson R, Amponsah KI, Gyan B, et al. In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana: Adeniacissampeloides (Planch.) Harms.,Terminaliaivorensis A. Chev, and ElaeisguineensisJacq. Pharmacognosy Research. 2012;4(4):225

Henson IE. A brief history of the oil palm. In: Palm Oil. Amsterdam, Netherlands: Elsevier; 2012. pp. 1-29

Mshana NR. Traditional Medicine and Pharmacopoeia: Contribution to the Revision of Ethnobotanical and Floristic Studies in Ghana. Accra, Ghana: Organization of African Unity/Scientific, Technical & Research Commission; 2000. 920 p

Calixto JB, Santos ARS, Filho VC, Yunes RA. A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology, and therapeutic potential. Medicinal Research Reviews. 1998;18(4):225-258

Gaire BP, Subedi L. Phytochemistry, pharmacology and medicinal properties of Phyllanthusemblica Linn. Chinese Journal of Integrative Medicine. 2014:1-8. DOI: 10.1007/s11655-014-1984-2

Mirunalini S, Krishnaveni M. Therapeutic potential of Phyllanthusemblica (amla): The ayurvedic wonder. Journal of Basic and Clinical Physiology and Pharmacology. 2010;21(1):93-105

Bagavan A, Rahuman AA, Kaushik NK, Sahal D. In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum. Parasitology Research. 2011;108(1):15-22

Mittal M, Gupta N, Parashar P, Mehra V, Khatri M. Phytochemical evaluation and pharmacological activity of Syzygiumaromaticum: A comprehensive review. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(8):67-72

Ichino C, Soonthornchareonnon N, Chuakul W, Kiyohara H, Ishiyama A, Sekiguchi H, et al. Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity. Phytotherapy Research. 2006;20(4):307-309

Sleumer HO. Flora neotropica: Monograph number 22. Flacourtiaceae. New York New York Bot Gard Organ Flora Neotrop 499p Illus, maps, keys. Icones, Maps Geog. 1980;4

De Mesquita ML, Grellier P, Mambu L, De Paula JE, Espindola LS. In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies. Journal of Ethnopharmacology. 2007;110(1):165-170

Lorenzi H. Brazilian trees. Vol. 2. Brazil: Institutoplantarum de estudos da flora; 2002

Luchi AE. Fibre pits in wood of Xylopiaemarginata Mart. (Annonaceae), ReservaBiológica e EstaçãoEcológica de Mogi-Guaçu, São Paulo State, Brazil. Hoehnea. 2016;43(3):517-520

Fern K, Fern A, Morris R. Useful tropical plants database. Recuper http// tropical theferns info. 2014

Porter AH. Neem: India’s Tree of Life. BBC News; 2006. p. 17

El Tahir A, Satti GMH, Khalid SA. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenussenegalensis (Lam.) Exell. Journal of Ethnopharmacology. 1999;64(3):227-233

Da Silva G, Serrano R, Silva O. Maytenusheterophylla and Maytenussenegalensis, two traditional herbal medicines. Journal of Natural Science, Biology and Medicine. 2011;2(1):59

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Published

2023-07-01

How to Cite

[1]
“Bark as Medicine: A Systematic Review of Pharmacological Properties and Therapeutic Benefits of Medicinal Plant Barks”, JASRAE, vol. 20, no. 3, pp. 338–344, Jul. 2023, Accessed: Oct. 06, 2024. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/14502

How to Cite

[1]
“Bark as Medicine: A Systematic Review of Pharmacological Properties and Therapeutic Benefits of Medicinal Plant Barks”, JASRAE, vol. 20, no. 3, pp. 338–344, Jul. 2023, Accessed: Oct. 06, 2024. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/14502