Synthesis and Characterization of Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents

Exploring the antimicrobial activity of novel 4-thiazolidinone derivatives

Abstract

A progression of new subsidiaries of 4-thiazolidinone were incorporated, recognized by unearthly procedures, and screened for antimicrobial movement. All the mixes were tried at convergences of 50, 100 , 200, 400, 800 and 1600 μgmL separately against five Gram-positive microscopic organisms, two Gram-negative microbes and two growths. Introductory inhibitory fixations were likewise settled for the two substances and were accounted for to be inside the scope of 100–400 μgmL. A considerable lot of the mixes showed mellow antimicrobial action to pleasant. The most dynamic mixes of the succession were mixes 4a [2-(4-fluoro-phenyl)- 3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-yl)- thiazolidin-4-one] and 4e [3-(4,6-dimethyl-pyrimidin-2-yl)- 2-(2-methoxy-phenyl)- thiazolidin-4-one], demonstrating checked antimicrobial action against Pseudomonas fluorescens, Staphylococcus aureus and parasitic strains. Hence it might be induced based on the discoveries acquired that combined mixes show a solid scope of antimicrobial activity.