Optimization of HPLC Measurements Using Addictive Drug Leflunomide and its Validation Studies under Different Medium

Exploring the Effects of Leflunomide on Rheumatoid and Psoriatic Arthritis

Authors

  • Suman Sharma
  • Dr. Satyavir .

Keywords:

Optimization, HPLC Measurements, Addictive Drug, Leflunomide, Validation Studies, Medium, Immunomodulatory drug, Dihydroorotate dehydrogenase, Pyrimidine synthesis, Anti proliferative activity

Abstract

The Leflunomide is an immunomodulatory drug inhibiting dihydroorotate dehydrogenase an enzyme involved in de novo pyrimidine synthesis. Genuine anti proliferative activity has been proven. Additionally, the several experimental models (both in vivo and in vitro) have demonstrated an anti-inflammatory effect. This double action is supposed to slow progression of the disease and to cause remission or relief of symptoms of rheumatoid arthritis and psoriatic arthritis such as joint tenderness and decreased joint and general mobility in human patients.

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Published

2018-04-01

How to Cite

[1]
“Optimization of HPLC Measurements Using Addictive Drug Leflunomide and its Validation Studies under Different Medium: Exploring the Effects of Leflunomide on Rheumatoid and Psoriatic Arthritis”, JASRAE, vol. 15, no. 1, pp. 312–317, Apr. 2018, Accessed: Jun. 27, 2025. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/7624

Issue

Vol. 15 No. 1 (2018): Journal of Advances and Scholarly Researches in Allied Education (JASRAE)

Section

Articles

How to Cite

[1]
“Optimization of HPLC Measurements Using Addictive Drug Leflunomide and its Validation Studies under Different Medium: Exploring the Effects of Leflunomide on Rheumatoid and Psoriatic Arthritis”, JASRAE, vol. 15, no. 1, pp. 312–317, Apr. 2018, Accessed: Jun. 27, 2025. [Online]. Available: https://ignited.in/index.php/jasrae/article/view/7624