The Outcome of Formulation and Processing Variables on the Stability of Levothyroxine Sodium Tablets

Impact of Processing and Formulation Factors on Levothyroxine Sodium Tablet Stability

Abstract

Stability of formulations over shelf-life is critical forhaving a quality product. Choice of excipients, manufacturing process, storageconditions, and packaging can either mitigate or enhance the degradation of theactive pharmaceutical ingredient [API], affecting potency and/or stability. Thepurpose was to investigate the influence of processing and formulation factorson stability of levothyroxine [API].