Hybrid Vesicular Formulation of Adapalene and Tea Tree Oil: A Targeted Strategy for Acne Management
DOI:
https://doi.org/10.29070/c1g41c42Keywords:
Niosomes, Acne vulgaris, Adapalene, Herbal bioactives, Tea tree oil, Lemongrass oil, Topical delivery, controlled release, Nanocarrier system, Anti-inflammatory formulationAbstract
Acne vulgaris is a multifactorial skin condition that often requires long-term management due to its chronic and relapsing nature. While conventional therapies provide temporary relief, their limitations—including side effects, resistance, and poor skin compatibility—necessitate the development of safer and more effective alternatives. This research focuses on designing a topical delivery system that merges the benefits of synthetic retinoids and herbal actives using niosomal technology. Niosomes, composed of non-ionic surfactants, offer enhanced drug stability, targeted delivery, and controlled release, making them an ideal carrier for cutaneous applications. In this formulation, Adapalene is combined with natural oils such as Tea Tree and Lemongrass—known for their antimicrobial and anti-inflammatory actions—to develop a stable, skin-friendly gel. The proposed system aims to overcome the common drawbacks of existing acne treatments while enhancing therapeutic efficacy and patient compliance. The findings suggest that the developed niosomal gel holds promise as a holistic and advanced approach to acne therapy.
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References
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