An Economic and Green Prospect For the Synthesis of Dihydropyrimidinones Using Microwave and Solid Acid Catalyst Under Solvent Free Condition-A Comparative Study

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Abstract

Cyclocondensationof β-ketoesters, aromatic aldehyde and urea is a key step forsynthesis of 3,4-hydropyrimidin-2-(1H)one.In this work we report a very simple procedure for this conversion by usingreusable, heterogeneous acidic media silica sulphuric acid in solvent freecondition using microwave with high efficiency.