Amerelioating Effect of Aloe Vera in Neurotoxin Induced Parkinsonian Disease: Behavioral Assessment with Tardive Dyskinesia Test in Albino Mice: The potential therapeutic effect of Aloe vera on neurotoxin-induced Parkinson's disease in Albino mice

Abstract

Aim Aloe vera is a well-known herbal drug that shows beneficial effects in the treatment of diabetes, skin disorders and also as an anti-inflammatory agent. Conventional method of treatment of Parkinson’s disease has untoward is its side effects. A. vera may prove to be beneficial in this regard. Materials and Methods Swiss albino mice were used in the study. They were divided into 6 groups containing 12 animals in each group. Group I served as (control). Group II received 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), was administered 20mgkg (2 doses) by intraperitoneal route. Group III IV were treated with A. vera in the dose of 200, and 400 mgkgday, orally respectively along with MPTP. Group V were administered Levodopa 30mgkg by intraperitoneal route along with MPTP. Tardive dyskinesia test were used to evaluate anti-parkinsonian effect on the7th day and on 15th day. Statistics One-way ANOVA followed by post-hoc Tukey test was used. Results A. vera in the dose of 200 and 400 mgkg given orally showed decrease in vacuous chewing movements (VCMs) which was significant as compared to MPTP treated group.Results Conclusions This study reveals beneficial effect of A. vera in MPTP induced animal model of Parkinson’s disease.