A Study of Pyrazole Derivative Synthesis and Characterization

Exploring the Potential of Pyrazole Derivatives as Antimicrobial Agents

Abstract

Pyrazoles and their variously substituted derivatives are important biological agents and substantial amount of study activity has been directed towards this class. In particular, they are used as antitumor, antibacterial and antifungal, antiviral, antiparasitic, antitubercular, insecticidal, anti-inflammatory, anti-diabetic, anesthetic and analgesic agents. A four new 1,3,5-trisubstituted pyrazole derivatives (2a-d) were synthesized from the reaction of corresponding 1,3-diaryl-2-propene-1-one compounds (1a-d) with phenyl hydrazine in glacial acetic acid. The pyrazole derivatives were divided for their antimicrobial activities in contradiction of several bacterial species and candida albicans.