A Study on the Biological Evaluation of Dihydropyridines

Effects of newly synthesised compounds on blood pressure in male rats

Authors

  • Dr. Surabhi Singh

Keywords:

biological evaluation, dihydropyridines, substituting, analogues, nifedipine, calcium channel blocker, synthesised compounds, blood pressure, male rats, tail-cuff procedure

Abstract

By substituting 1-(4-Nitrobenzyl)-5-imidazolyl or 2-methylthio-1-(4-Nitrobenzyl)-5-imidazolyl for the orthonitrophenyl group on location 4, new analogues of nifedipine, an established calcium channel blocker, were synthesised. In male rats, the effects of the newly synthesised compounds on blood pressure were analysed using an indirect tail-cuff procedure at 15, 30, and 60 minutes after administration and compared to nifedipine.

Downloads

Published

2021-04-01

How to Cite

[1]
“A Study on the Biological Evaluation of Dihydropyridines: Effects of newly synthesised compounds on blood pressure in male rats”, JASRAE, vol. 18, no. 3, pp. 33–38, Apr. 2021, Accessed: Jul. 03, 2024. [Online]. Available: https://ignited.in/jasrae/article/view/13079

Issue

Vol. 18 No. 3 (2021): Journal of Advances and Scholarly Researches in Allied Education (JASRAE)

Section

Articles

How to Cite

[1]
“A Study on the Biological Evaluation of Dihydropyridines: Effects of newly synthesised compounds on blood pressure in male rats”, JASRAE, vol. 18, no. 3, pp. 33–38, Apr. 2021, Accessed: Jul. 03, 2024. [Online]. Available: https://ignited.in/jasrae/article/view/13079