Pharmacological Innovations and Challenges in Cancer-Targeted Therapies

Authors

  • Abdullah Ibrahim Henishi Pharmacist, Prince Sultan Military Medical City, Riyadh KSA
  • Hussam Ibrahim Alasiri Pharmacist, Prince Sultan Military Medical City, Riyadh KSA
  • Ahmed Abdullah Alharbi Pharmacist, Prince Sultan Military Medical City, Riyadh KSA
  • Malek Yahya Albishri Pharmacist, Prince Sultan Military Medical City, Riyadh KSA
  • Ahmed Saeed Alzahrany Pharmacist, Prince Sultan Military Medical City, Riyadh KSA

Keywords:

pharmacological innovations, cancer-targeted therapies, oncology treatment, molecular changes, tumor growth, key molecules, tumorigenesis, small molecule inhibitors, monoclonal antibodies, immunotherapies, gene therapies, obtained drug resistance, heterogeneous tumor responses, predictive biomarkers, targeted healing procedures, tumor biology, drug development strategies, resistance mechanisms, precision medicine, healthcare systems, accessibility, collaborative initiatives, cancer treatment

Abstract

Cancer-centered therapies have revolutionized the panorama of oncology treatment, impartingpromising challenges to cope with unique molecular changes driving tumor growth and progression.Over the past few decades, big strides have been made in pharmacological innovations towarddesigning drugs that selectively goal key molecules worried in tumorigenesis, such as oncogenes,increase factors, and signaling pathways. The development of small molecule inhibitors, monoclonalantibodies, immunotherapies, and gene therapies has supplied tailor-made alternatives for variouscancers kinds, enhancing treatment efficacy while minimizing systemic toxicity. However, despite theseimprovements, demanding situations persist, including obtained drug resistance, heterogeneous tumorresponses, and the want for predictive biomarkers to guide patient selection. Additionally, the high valueof targeted healing procedures and the complexity of tumor biology obstacles to considerableaccessibility. Addressing these challenges calls for concerted efforts in refining drug improvementstrategies, elucidating resistance mechanisms, advancing precision medicinal drug strategies, andoptimizing healthcare structures for equitable admission to revolutionary cancer treatments. Theongoing research endeavors and collaborative initiatives geared toward overcoming those hurdlesmaintain promise for similarly enhancing the effectiveness and accessibility of centered healingprocedures within the combat in opposition to cancer.

References

Beg, S., & Rahman, M. (2022). Nanomedicine for Cancer: Targeted Therapy, Vaccination, Pharmacokinetics, and Challenges. Current Drug Metabolism, 23(8), 586–586. https://doi.org/10.2174/138920022308221111164626

Crisci, S., Amitrano, F., Saggese, M., Muto, T., Sarno, S., Mele, S., Vitale, P., Ronga, G., Berretta, M., & Di Francia, R. (2019). Overview of Current Targeted Anti-Cancer Drugs for Therapy in Onco-Hematology. Medicina, 55(8). https://doi.org/10.3390/medicina55080414

Fountzilas, E., & Tsimberidou, A. M. (2018). Overview of precision oncology trials: challenges and opportunities. Expert Review of Clinical Pharmacology, 11(8), 797–804. https://doi.org/10.1080/17512433.2018.1504677

Fu, C., Yu, L., Miao, Y., Liu, X., Yu, Z., & Wei, M. (2023). Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope? Acta Pharmaceutica Sinica B, 13(2), 498–516. https://doi.org/10.1016/j.apsb.2022.07.020

Fu, Z., Li, S., Han, S., Shi, C., & Zhang, Y. (2022). Antibody-drug conjugate: the "biological missile" for targeted cancer therapy. Signal Transduction and Targeted Therapy, 7(1). https://doi.org/10.1038/s41392-022-00947-7

He, S., Du, Y., Tao, H., & Duan, H. (2023). Advances in aptamer-mediated targeted delivery system for cancer treatment. International Journal of Biological Macromolecules, 238, 124173. https://doi.org/10.1016/j.ijbiomac.2023.124173

Hsu, J. C., Jia Yu Lin, Lin, P., & Yang Cheng Lee. (2019). Comprehensive value assessment of drugs using a multi-criteria decision analysis: An example of targeted therapies for metastatic colorectal cancer treatment. PLOS ONE, 14(12), e0225938–e0225938. https://doi.org/10.1371/journal.pone.0225938

Kumar, A., & Kumar, A. (2023). Chitosan-Based Drug Conjugated Nanocomposites: Advances and Innovation in Cancer Therapy. Regenerative Engineering and Translational Medicine. https://doi.org/10.1007/s40883-023-00310-4

Luiza Steffens Reinhardt, Cox, M., Jussânia Gnoatto, Wawruszak, A., Hałasa, M., Pablo Ricardo Arantes, Rowan, N. J., & Dinara Jaqueline Moura. (2021). Polymeric Nanocomposites for Cancer-Targeted Drug Delivery. Advances in Material Research and Technology, 241–270. https://doi.org/10.1007/978-3-030-70266-3_8

Magalhaes, L. G., Ferreira, L. L. G., Andricopulo, A. D., Magalhaes, L. G., Ferreira, L. L. G., & Andricopulo, A. D. (2018). Recent Advances and Perspectives in Cancer Drug Design. Anais Da Academia Brasileira de Ciências, 90(1), 1233–1250. https://doi.org/10.1590/0001-3765201820170823

Mereiter, S., Balmaña, M., Campos, D., Gomes, J., & Reis, C. A. (2019). Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading? Cancer Cell, 36(1), 6–16. https://doi.org/10.1016/j.ccell.2019.06.006

Pereira-Silva, M., Alvarez-Lorenzo, C., Concheiro, A., Santos, A. C., Veiga, F., & Figueiras, A. (2020). Nanomedicine in osteosarcoma therapy: Micelleplexes for delivery of nucleic acids and drugs toward osteosarcoma-targeted therapies. European Journal of Pharmaceutics and Biopharmaceutics, 148, 88–106. https://doi.org/10.1016/j.ejpb.2019.10.013

Su, C., Ren, X., Nie, F., Li, T., Lv, W., Li, H., & Zhang, Y. (2021). Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives. RSC Advances, 11(21), 12915–12928. https://doi.org/10.1039/d0ra08727k

Subhan, A., & Torchilin, V. P. (2023). Advances in Targeted Therapy of Breast Cancer with Antibody-Drug Conjugate. Pharmaceutics, 15(4), 1242–1242. https://doi.org/10.3390/pharmaceutics15041242

Sun, X., Liu, K., Lu, S., He, W., & Du, Z. (2022). Targeted Therapy and Immunotherapy for Heterogeneous Breast Cancer. Cancers, 14(21), 5456. https://doi.org/10.3390/cancers14215456

Tang, L., Li, J., Zhao, Q., Pan, T., Zhong, H., & Wang, W. (2021). Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery. Pharmaceutics, 13(8), 1151. https://doi.org/10.3390/pharmaceutics13081151

Wang, S., Chen, Y., Guo, J., & Huang, Q. (2023). Liposomes for Tumor Targeted Therapy: A Review. International Journal of Molecular Sciences, 24(3), 2643. https://doi.org/10.3390/ijms24032643

Wang, W., Chen, K., Su, Y., Zhang, J., Li, M., & Zhou, J. (2018). Lysosome-Independent Intracellular Drug/Gene Codelivery by Lipoprotein-Derived Nanovector for Synergistic Apoptosis-Inducing Cancer-Targeted Therapy. Biomacromolecules, 19(2), 438–448. https://doi.org/10.1021/acs.biomac.7b01549

Yoon, A-Rum., Hong, J., Jung, B., Ahn, H., Zhang, S. N., & Yun, C. (2023). Oncolytic adenovirus as pancreatic cancer-targeted therapy: Where do we go from here? Cancer Letters, 216456–216456. https://doi.org/10.1016/j.canlet.2023.216456

Zhang, H., Dong, S., Li, Z., Feng, X., Xu, W., Mae, C., Jiang, Y., & Ding, J. (2020). Biointerface engineering nanoplatforms for cancer-targeted drug delivery. Asian Journal of Pharmaceutical Sciences, 15(4), 397–415. https://doi.org/10.1016/j.ajps.2019.11.004

Zhang, M., Hu, S., Liu, L., Dang, P., Liu, Y., Sun, Z., Qiao, B., & Wang, C. (2023). Engineered exosomes from different sources for cancer-targeted therapy. Signal Transduction and Targeted Therapy, 8, 124. https://doi.org/10.1038/s41392-023-01382-y

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Published

2023-10-01

How to Cite

[1]
“Pharmacological Innovations and Challenges in Cancer-Targeted Therapies”, JASRAE, vol. 20, no. 4, pp. 219–224, Oct. 2023, Accessed: Jun. 29, 2024. [Online]. Available: https://ignited.in/jasrae/article/view/14539

How to Cite

[1]
“Pharmacological Innovations and Challenges in Cancer-Targeted Therapies”, JASRAE, vol. 20, no. 4, pp. 219–224, Oct. 2023, Accessed: Jun. 29, 2024. [Online]. Available: https://ignited.in/jasrae/article/view/14539