A Study of Antibacterial Potential of Solid Lipid Nanoparticles loaded with Anethi Aetheroleum
Keywords:
Antibacterial Potential, Solid Lipid, Nanoparticles, Anethi AetheroleumAbstract
Essential oils are being researched as antimicrobial agents to fight infectious disorders due to antibiotic resistance. This work loads dill essential oil, Anethi aetheroleum, into solid lipid nanoparticles (SLNs) and tests their antibacterial efficacy. Effectively administering essential oils using SLNs increases bioavailability and stability. A modified solvent emulsification-evaporation approach created Anethi aetheroleum-containing SLNs. They were then tested for physicochemical qualities and antibacterial activity against many harmful pathogens. Enveloping the Anethi aetheroleum in SLNs created stable nanostructures with the right shape and particle size. Anethi aetheroleum-loaded SLNs were highly effective against bacteria in antibacterial testing. Given these findings, SLNs should be carefully examined as a way to distribute essential oils, particularly Anethi aetheroleum, to fight bacterial infections and reduce antibiotic resistance.
References
Kovacevic, S., & Keck, C. M. (2015). Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on size, physical stability & particle matrix structure. International Journal of Pharmaceutics, 406(1-2), 163–172.
Parthiban, S., & Senthilkumar, G. P. (2018). A modern review on SLN as a novel controlled drug delivery system. International Journal of Research in Pharmaceutical and Nano Sciences, 3(4), 313–325.
Lippacher, K., & Müller, R. H. (2020). Investigations on the viscoelastic properties of lipid-based colloidal drug carriers. International Journal of Pharmaceutics, 196, 227–230.
Gomba, C., & Volka, K. (2017). Interactions of SLN with model membranes & leukocytes studied by EPR. International Journal of Pharmaceutics, 256, 133–140.
Sentjurc, M., & Strancar, J. (2020). Influence of spin probe structure on its distribution in SLN dispersions. International Journal of Pharmaceutics, 196, 241–244.
Allahverdiyev, & Bagirova, M. (2017). Coping with antibiotic resistance: Combining nanoparticles with antibiotics and other antimicrobial agents. Expert Review of Anti-infective Therapy, 9, 1035–1052.
Alvarez-Román, & Guy, R. H. (2018). Enhancement of topical delivery from biodegradable nanoparticles. Pharmaceutical Research, 21, 1818–1825.
Barre, J. T., & Janairo, G. C. (2017). A bioactive triterpene from L. camara. Phytochemistry, 45, 321–324.
Porter, J. H. (2018). Formulation of lipid-based delivery systems for oral administration: Materials, methods & strategies. Advanced Drug Delivery Reviews, 60(6), 625–637.
Barthelemy & Jaochim, J. (2019). Compritol® 888 ATO: Innovative hot melt coating agent for prolonged-release drug formulations. European Journal of Pharmaceutics and Biopharmaceutics, 47, 87–90.
Damte, D., & Park, S.-C. (2021). Antimicrobial activity of lemongrass & oregano essential oils against standard antibiotic-resistant S. aureus & field isolates from chronic mastitis cow. International Journal of Phytomedicine, 4, 134–139.
Benoit, J., & Pech, B. (2020). Physicochemical stability of colloidal lipid particles. Biomaterials, 24, 4283–4300.
Constantinides, P. P., & Yiv, S. H. (2019). Particle size determination of phase-inverted w/o emulsions under different dilution & storage conditions. International Journal of Pharmaceutics, 115, 225–234.
Ma, B., Huang, B., (2018). Interference & Mechanism of Dill Seeds Essential Oil & Contribution of Carvone & Limonene in Preventing Sclerotinia Rot of Rapeseed. PLOS ONE, 10(7), e0131733.
Holemwerger, S. V., & Sampaio, C. (2017). Essential oil from Z. tingoassuiba loaded into multilamellar liposomes useful as antimicrobial agents. Journal of Microencapsulation, 26, 684–691.
Borris, R. P. (2016). Natural products research: Perspectives from a major pharmaceutical company. Journal of Ethnopharmacology, 51, 29–38.
Pandian, S. K. (2019). Eugenol (essential oil of clove) acts as an antibacterial agent against S. typhi by disrupting the cellular membrane. Journal of Ethnopharmacology, 130, 107–115.
Vincensia, M., & Ferrarib, G. (2018). Design of nanoemulsion-based delivery systems of natural antimicrobials: Effect of the emulsifier. Journal of Biotechnology, 159, 342–350.
Woodard, G., & Calvery, H. O. (2017). Methods for the study of irritation & toxicity of substances applied topically to the skin & mucous membranes. Journal of Pharmacology and Experimental Therapeutics, 82, 377–390.
Fujioka, T., & Kashiwada, Y. (2017). Anti-AIDS agents. 11. Betulinic acid & platanic acid as antiHIV principles from S. clavifloruym & the antiHIV activity of structurally related triterpenoids. Journal of Natural Products, 57, 243–247.
Ghoshal, S., & Krishna Prasad, B. N. (2016). Anti-amoebic activity of P. longum fruits against E. histolytica in vitro & in vivo. Journal of Ethnopharmacology, 50, 167–170.
Habtemariam, S., & Gray, A. I. (2015). A new antibacterial sesquiterpene from P. oligotricha. Journal of Natural Products, 56, 140–143.
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