Synthesis, Characterization and Antimicrobial Activity of Homonuclear Cu(II) and Ni(II) Schiff Base Complexes

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Published: Sep 2, 2024
DOI: https://doi.org/10.29070/cp5vsm97
Keywords:
Schiff base, Homonuclear complexes, BSA/DNA–binding, Cytotoxicity, Metal complex Cu(II) and Ni(II)

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Authors

Indira Priyadarshini

PG Department of Chemistry, Magadh University, Bodh Gaya - 824234, India

Dr. Rajesh Ranjan Pandey

Department of Chemistry, Anugrah Memorial College (Magadh University, Bodh Gaya) - 823001, India

Abstract

The current study aimed to synthesise, characterise, and investigate the antimicrobial activity of homonuclear Cu(II) and Ni(II) Schiff base complexes. Homonuclear Schiff Base Complexes chelates of Cu(II) and Ni(II) were synthesised. It appears that the complex is a potential metallo-ligand. It forms binuclear complexes when it reacts with two different metal salts, Ni and Cu. Using a Schiff base ligand made from 4-chloro-o-phenylenediamine and 3,5-dichloro-2-hydroxyacetophenone, the homo and hetero binuclear oxygen bridging Cu(II) and Ni(II) complexes were synthesized. Numerous common physicochemical methods, including elemental analysis, spectroscopic, thermal, cyclic voltammetry, and magnetic moment tests, have been used to characterise the synthesised complexes. For the mono- and binuclear compound of Cu(II) & Ni(II), spectral analysis reveals square planer shape. The antibacterial data indicates that the homo-binuclear copper complex is more active than the other mono- and binuclear complexes. Research has been done on the Schiff base and its complexes' anticancer properties.

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Issue

Vol. 20 No. 2 (2023): Journal of Advances in Science and Technology (JAST)

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