An Analysis upon Some Novel Heterocyclic Compounds with Antimicrobial Activity: Exploring the Biological Activity and Molecular Interactions of Heterocyclic Compounds

Abstract

2-Chloro–N-{4-(4-chlorophenyl)-6-[4-{dimethylamino) phenyl] pyrimidin-2-yl} acetamide were allowed to react separately with different secondary amines in presence of alkaline medium to yield the corresponding secondary amine derivatives substituted heterocycls. The compounds obtained were identified by spectral data and screened for antimicrobial activity. The result shows that all samples are more or less active agents against various microorganisms.Among heterocyclic compounds five-membered heterocycles constitute a wide and differentiated group with broad spectrum of biological activity. The systems with different kind and number of heteroatoms are described. Among each subgroup structure-activity relationships and pharmacophore models are discussed as well as interactions with the molecular target.