Regioselective Palladium Catalyzed Cross-Coupling of Oxazoles: Applications of Palladium Catalysis in the Functionalization of Oxazoles

Abstract

Asurvey blanket the writing until April 2008 concerning organometallic reactionsto funcionalise oxazoles is portrayed. An order for the functionalisation ofthe oxazole 2-and 4-positions utilizing the Suzuki coupling response isportrayed. 2-Aryl-4-trifloyloxazoles experience quick, microwave-aided couplingwith an extent of aryl and heteroaryl boronic acids in great to fantasticyields. The technique is so also viable utilizing 4-aryl-2-chlorooxazoles asthe coupling mate and has been augmented to the union of a novel class ofhomo-and heterodimeric 4,4- interfaced dioxazoles. Moreover, a regioselectiveSuzuki-Miyaura cross-coupling of 2,4-dihalooxazoles emulated by a Stillecoupling has been effectually improved. Thestrategy bears focalized blends of trisoxazoles in towering yield and in aleast number of steps. Besides, C-2 coordinate arylation of oxazoles isexamined. This procedure is developed to the blend of C2-C4' interfaced bis andtris oxazoles of the sort discovered in the Ulapualide A group of common items.