Studies on Propranolol hydrochloride floating tablets formulated with different concentrations of Aegle marmelos gum

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Published: Sep 2, 2024
DOI: https://doi.org/10.29070/f97k6921
Keywords:
Propranolol hydrochloride, floating tablets, Aegle marmelos gum, natural polymer, bioavailability

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Authors

Dr. Eman Nazmi Al Qutub

Senior Pharmacist, PSMMC

Dr. Khoulod Nazmi Al Qutub

Pharmacist, Al Yammamah. Hospital

Dr. Dr. Manal Nazmi Al Qutub

Endodontic Consultant, PNU (Princess Nourah bint Abdullrahman)

Abstract

This research employs Aegle marmelos gum in various ratios as a natural polymer to formulate and assess Propranolol hydrochloride floating tablets. Because of its high solubility and permeability, propranolol hydrochloride, a non-selective beta-adrenergic receptor blocker, has a restricted bioavailability. Floating tablets are intended to improve the absorption and bioavailability of drugs by staying afloat in the stomach. Aegle marmelos gum (AMG) was used as a polymer in varied ratios to create distinct formulations. The tablets were then tested for a number of characteristics, including hardness, friability, drug content, in vitro buoyancy, and drug release profiles. The findings showed that the Aegle marmelos gum content had a major impact on the tablets' floating qualities and drug release characteristics.

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Article Details

Issue

Vol. 20 No. 2 (2023): Journal of Advances in Science and Technology (JAST)

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References

  1. Iannuccelli V, Coppi G, Bernabei MT, Cameroni R. Air compartment multiple-unit system for prolonged gastric residence. Part I. Formulation study. Int J Pharm. 1998;174:47–54.
  2. Gutierrez-Rocca J, Omidian H, Shah K. Progresses in Gastroretentive drug delivery systems. Pharmatech. 2003:152–156.
  3. Sungthongjeen S, Paeratakul O, Limmatvapirat S, Puttipipatkhachorn S. Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique. Int J Pharm. 2006;324:136–143.
  4. Gilman Goodman. NY. 10th ed. McGraw-Hill; 2001. Goodman and Gilman’s the pharmacological basis of therapeutics; pp. 871–872.
  5. Huang YB, Tsai YH, Yang WC, Chang JS, Wu PC, Takayama K. Once-daily propranolol extended-release tablet dosage form: formulation design and in vitro/in vivo investigation. Eur J Pharm Biopharm. 2004;58:607–614.
  6. Takka S, Rajbhandari S, Sakr A. Effect of anionic polymer on the release of propranolol hydrochloride from matrix tablets. Eur J Pharm Biopharm. 2001;52:75–82.
  7. Martin A, Bustamante P, Chun A. Physical Pharmacy-Physical Chemical Principles in the Pharmaceutical Sciences. 4th ed. Baltimore: Lippincott Williams and Wilkins; 2002. Micromeritics; pp. 446–448.
  8. Aulton ME, editor. Pharmaceutics – the Science of Dosage Form Design. 2nd ed. London: Churchill Livingstone; 2002. Powder flow; pp. 207–208.
  9. Korsmeyer RW, Gurny R, Docler E, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15:25–35.
  10. Higuchi T. Mechanism of sustained-action medication: theoretical analysis of rate of release of solid drugs dispersed in soled matrices. J Pharm Sci. 1963;52:1145–1148.
  11. Varshosaz J, Tavakoli N, Roozbahani F. Formulation and in vitro characterization of Ciprofloxacin floating and bioadhesive extended-release tablets. Drug Del. 2006;13:277–285.
  12. Goole J, Vanderbist F, Amighi K. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. Int J Pharm. 2007;334:35–41.
  13. Chavanpatil MD, Jain P, Chaudhari S, Shear R, Vavia PR. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. Int J Pharm. 2006;316:86–92.
  14. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release. 2000;63:235–259.
  15. Dabbagh MA, Ford JL, Rubinstein MH, Hogan JE, Rajabi-Siahboomi AR. Release of propranolol hydrochloride from matrix tablets containing sodium carboxymethycellulose. Pharm Dev Tech. 1999;4:313–324.
  16. Niranjanpatra C, Bharanikumar A, Pandit HK, Singh SP, Vimaladevi M. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Acta Pharm. 2007;57:479–489.
  17. Vaghani S, Vasanti S, Chaturvedi K, Satish CS, Shankar SJ. Formulation and Evaluation of 5-FU Loaded Eudragit Microspheres: Effect of Various Eudragit on Micromeretic Properties of Microspheres. J Macromol Sci Part A Pure Appl Chem. 2008;45:1015–1027.
  18. Sahoo SK, Mallick AA, Barik BB, Senapati PC. Formulation and in vitro evaluation of eudragit microspheres of stavudine. Trop J Pharm Res. 2005;4:369–375.
  19. Yang GM, Kuo JF, Woo EM. Preparation and control-release kinetics of isosorbide dinitrate microspheres. J Microencapsul. 2006;23:622–631. doi:10.1080/02652040600776465.
  20. Dave BS, Amin AF, Patel MM. Gastroretentive drug delivery system of ranitidine hydrochloride: Formulation and in vitro evaluation. AAPS Pharm Sci Tech. 2004;5:77–82.