Medical Devices Using Nanotechnology to Treat Chronic Skin Lesions
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When it comes to treating chronic skin lesions, nanotechnology has shown great promise. It provides novel ways to overcome the drawbacks of conventional therapy. Pressure sores and diabetic ulcers are examples of chronic skin disorders that present considerable challenges because of their persistence and resistance to traditional therapies. Precision drug delivery, increased tissue regeneration, and better wound healing are all made possible by nanotechnology through the use of nanoparticles, nanofibers, and nano-coatings. This review delves into the ways that nanotechnology is being used in medical devices intended for skin treatment, including improvements in antimicrobial dressings, medication delivery systems, wound healing materials, and skin graft upgrades. Furthermore, it emphasises how dynamic, on-demand wound care could be revolutionised by responsive nanomaterials and nanobots. Notwithstanding these developments, expanding production and negotiating complicated regulatory environments continue to provide difficulties. The successful application of nanotechnology in healthcare depends on guaranteeing the efficacy and safety of nanomaterials as well as resolving ethical issues with patient consent and long-term impacts. In order to address unmet medical requirements, future research and development must concentrate on regulating standards, discovering novel combinations of nanotechnology, and optimising the properties of nanomaterials. This analysis comes to the conclusion that although nanotechnology has enormous potential to revolutionise the treatment of chronic skin lesions, its complete adoption will necessitate overcoming ethical, legal, and technical obstacles in addition to ongoing cross-disciplinary collaboration and scientific innovation.
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- Ahamed, M., AlSalhi, M. S., & Siddiqui, M. K. J. (2010). Silver nanoparticle applications and human health. Clinica Chimica Acta, 411(23-24), 1841-1848.
- Balasubramanian, K., & Burghard, M. (2005). Chemically functionalized carbon nanotubes. Small, 1(2), 180-192.
- Barani, M., Montazerian, M., & Mirpoor, S. (2019). Nanotechnology in wound healing: A comprehensive review. Pharmaceutics, 11(9), 445.
- Bawa, R. (2010). Nanoparticle-based therapeutics in humans: A survey. Nanotechnology Law & Business, 7(2), 135-155.
- Bhowmick, S., Mazumder, A., & Chattopadhyay, D. (2018). Nanotechnology in skin regeneration. Nanomedicine: Nanotechnology, Biology, and Medicine, 14(4), 2555-2562.
- Bhushan, B. (Ed.). (2017). Springer handbook of nanotechnology. Springer.
- Bjarnsholt, T., Kirketerp-Møller, K., Jensen, P. Ø., Madsen, K. G., Phipps, R., Krogfelt, K., Høiby, N., & Givskov, M. (2008). Why chronic wounds will not heal: A novel hypothesis. Wound Repair and Regeneration, 16(1), 2-10.
- Boateng, J. S., & Catanzano, O. (2015). Advanced therapeutic dressings for effective wound healing—a review. Journal of Pharmaceutical Sciences, 104(11), 3653-3680.
- Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., & Donaldson, K. (2001). Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicology and Applied Pharmacology, 175(3), 191-199.
- Burd, A., Kwok, C. H., Hung, S. C., Chan, H. K., Gu, H., & Lam, W. K. (2007). A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models. Wound Repair and Regeneration, 15(1), 94-104.
- Chaloupka, K., Malam, Y., & Seifalian, A. M. (2010). Nanosilver as a new generation of nanoproduct in biomedical applications. Trends in Biotechnology, 28(11), 580-588.
- Chauhan, A., Saha, P., & Verma, M. (2016). Ethical issues in nanotechnology. Indian Journal of Pharmaceutical Education and Research, 50(3), S135-S146.
- Chen, V. J., & Ma, P. X. (2008). Nano-fibrous poly-l-lactic acid scaffolds with interconnected spherical macropores. Biomaterials, 25(11), 2065-2073.
- Choi, J. S., Lee, S. J., & Christ, G. J. (2008). Nano-fibrous scaffolds for tissue engineering and regenerative medicine. Journal of Biomedicine and Biotechnology, 2008, 840323.
- Chowdhury, E. H., Akaike, T., & Tanaka, J. (2012). Nanotechnology applications in healthcare. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(5), 688-690.
- Diegelmann, R. F., & Evans, M. C. (2004). Wound healing: An overview of acute, fibrotic and delayed healing. Frontiers in Bioscience, 9, 283-289.
- Duncan, R., & Gaspar, R. (2011). Nanomedicine(s) under the microscope. Molecular Pharmaceutics, 8(6), 2101-2141.
- EMA. (2011). Reflection paper on nanotechnology-based medicinal products for human use.
- Eming, S. A., Martin, P., & Tomic-Canic, M. (2014). Wound repair and regeneration: Mechanisms, signaling, and translation. Science Translational Medicine, 6(265), 265sr6.
- Fadeel, B., Feliu, N., Vogt, C., Abdelmonem, A. M., & Parak, W. J. (2018). Bridge over troubled waters: Understanding the synthetic and biological identities of engineered nanomaterials. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 11(3), e1512.
- Falanga, V. (2005). Wound healing and its impairment in the diabetic foot. The Lancet, 366(9498), 1736-1743.
- FDA. (2014). FDA guidance for industry: Considering whether an FDA-regulated product involves the application of nanotechnology.
- Gaharwar, A. K., Singh, I., & Khademhosseini, A. (2020). Engineered biomaterials for skin wound healing. Biomedical Engineering Advances, 11(3), 467-490.
- Jain, K. K. (2008). The handbook of nanomedicine. Springer Science & Business Media.
- Jang, J., Lee, D. S., & Kim, K. S. (2017). Nanocomposite biomaterials for tissue engineering and regenerative medicine. Nano Today, 13, 36-52.
- Kamath, M. S., & Ahmed, S. S. (2020). Nanotechnology in wound healing: Potentials and challenges. Emerging Applications of Nanoparticles and Architecture Nanostructures, 107(2), 65-80.
- Khanna, P., Ong, C., Bay, B. H., & Baeg, G. H. (2014). Nanotoxicity: An interplay of oxidative stress, inflammation and cell death. Nanomaterials, 5(2), 635-666.
- Khushf, G. (2007). Upstream ethics in nanomedicine: A call for research. Nanomedicine, 2(4), 511-521.
- Kim, J., Lee, J., & Ko, S. H. (2019). Nanomaterials in skin tissue engineering and regenerative medicine. Advanced Drug Delivery Reviews, 146, 209-230.
- Kreuter, J. (2001). Nanoparticulate systems for brain delivery of drugs. Advanced Drug Delivery Reviews, 47(1), 65-81.
- Kuroda, K., & Okuda, K. (2019). Antimicrobial peptides in the skin barrier: Nanotechnological advancements in dermatology. Journal of Nanobiotechnology, 17(1), 1-10.
- Ma, P. X., & Zhang, R. (2011). Nano-fibrous scaffolding architecture for tissue engineering. Annals of Biomedical Engineering, 29(12), 123-133.
- Ma, P. X., & Zhang, R. (2011). Nano-fibrous scaffolding architecture for tissue engineering. Annals of Biomedical Engineering, 29(12), 123-133.
- Martinez-Santamaria, L., Hernandez-Barrera, R., & Gonzalez-Cruz, J. (2016). Advances in nanotechnology for wound healing applications. Journal of Applied Polymer Science, 133(7), 432-439.
- Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007). Nanocarriers as an emerging platform for cancer therapy. Nature Nanotechnology, 2(12), 751-760.
- Pham, Q. P., Sharma, U., & Mikos, A. G. (2006). Electrospinning of polymeric nanofibers for tissue engineering applications: A review. Tissue Engineering, 12(5), 1197-1211.
- Rajendran, S., Anand, S. C., & Dias, T. (2021). Nanofibers and nanocomposites for wound healing. Nanomedicine: Nanotechnology, Biology, and Medicine, 15(1), 71-82.
- Sahoo, S. K., Parveen, S., & Panda, J. J. (2007). The present and future of nanotechnology in human health care. Nanomedicine: Nanotechnology, Biology, and Medicine, 3(1), 20-31.
- Sandler, R. (2009). Nanotechnology: The social and ethical issues. Woodrow Wilson International Center for Scholars.
- Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009). Human skin wounds: A major and snowballing threat to public health and the economy. Wound Repair and Regeneration, 17(6), 763-771.
- Tamayol, A., Najafabadi, A. H., & Annabi, N. (2015). Hydrogel coatings for wound healing and tissue regeneration. Journal of Nanotechnology in Engineering and Medicine, 6(3), 21-34.
- Torchilin, V. P. (2005). Recent advances with liposomes as pharmaceutical carriers. Nature Reviews Drug Discovery, 4(2), 145-160.
- Wagner, V., Dullaart, A., Bock, A. K., & Zweck, A. (2006). The emerging nanomedicine landscape. Nature Biotechnology, 24(10), 1211-1217.
- Zhang, L., Pornpattananangkul, D., Hu, C. M. J., & Huang, C. M. (2013). Development of nanoparticles for antimicrobial drug delivery. Current Medicinal Chemistry, 17(6), 585-594.
- Zhou, F., Hong, Y., & Zhang, X. (2018). Nanomaterials for cancer immunotherapy: Current progress and challenges. Advanced Materials, 30(24), 1706020.